Department of Internal Medicine, Long Island College Hospital, New York, NY, USA.
Am J Ther. 2009 Nov-Dec;16(6):591-2. doi: 10.1097/MJT.0b013e31818d5f6d.
Acute generalized exanthematous pustulosis (AGEP) is a rare disorder characterized by an acute episode and sudden onset of erythematous and edematous eruptions of hundreds of sterile pustules. It is a self-limiting condition accompanied by fever and has a rapid course. It is mostly caused by drugs especially antibiotics. It is diagnosed by skin biopsy, which shows intracorneal pustules and neutrophilic infiltration in dermis and epidermis. We report a case of a patient who developed this rare skin condition with the use of piperacillin/tazobactam (Zosyn). This is only second case of AGEP reported in literature with the use of Zosyn.
急性泛发性发疹性脓疱病（AGEP）是一种罕见的疾病，其特征为急性发作和突然出现数百个无菌脓疱的红斑和水肿性皮疹。它是一种伴有发热的自限性疾病，病程迅速。它主要由药物引起，特别是抗生素。它的诊断依据是皮肤活检，显示角质内脓疱和真皮和表皮中的中性粒细胞浸润。我们报告了一例使用哌拉西林/他唑巴坦（Zosyn）引起这种罕见皮肤病的患者。这是文献中第二例使用 Zosyn 引起的 AGEP 病例。
