Kyriakou Aikaterini, Zagalioti Sofia-Chrysovalantou, Patsatsi Aikaterini, Galanis Nikiforos, Lazaridou Elizabeth
Second Department of Dermatology and Venereology, Medical School, Aristotle University of Thessaloniki, Greece.
Papageorgiou Hospital, Thessaloniki, Greece.
Case Rep Dermatol Med. 2019 Apr 24;2019:3273987. doi: 10.1155/2019/3273987. eCollection 2019.
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction mainly attributed to antibiotics. It is characterized by numerous, nonfollicular, sterile pustules, arising on an exanthematous and edematous base. It is a serious adverse reaction accompanied by fever and leukocytosis. Piperacillin/tazobactam is indicated for the treatment of patients with moderate to severe infections. Herein is reported a case of AGEP caused by piperacillin/tazobactam. A 78-year-old woman with metastatic breast cancer was presented to the emergency department reporting fever and groin pain. The laboratory analysis and more specifically urine cultivation showed a urinary tract infection by with sensitivity to piperacillin/tazobactam. She had no known allergies. She was started on intravenous piperacillin/tazobactam; she improved clinically on the second day, but on the fourth day of intravenous therapy, she developed extensive pustular rash on the folds and anterior proximal thighs, accompanied by fever and neutrophilia. Piperacillin/tazobactam administration was interrupted and she was given prednisolone for ten days. The patient improved clinically and her laboratory tests returned to normal after two weeks. AGEP is an uncommon side effect of piperacillin/tazobactam treatment and there are few cases reported.
急性泛发性脓疱病（AGEP）是一种罕见的皮肤不良反应，主要归因于抗生素。其特征为在红斑水肿基础上出现大量非毛囊性无菌脓疱。它是一种伴有发热和白细胞增多的严重不良反应。哌拉西林/他唑巴坦适用于治疗中重度感染患者。本文报告了一例由哌拉西林/他唑巴坦引起的AGEP病例。一名78岁转移性乳腺癌女性因发热和腹股沟疼痛就诊于急诊科。实验室分析尤其是尿液培养显示存在尿路感染，对哌拉西林/他唑巴坦敏感。她无已知过敏史。开始静脉输注哌拉西林/他唑巴坦；第二天临床症状有所改善，但在静脉治疗第四天，她在褶皱处和大腿近端前部出现广泛脓疱性皮疹，伴有发热和中性粒细胞增多。哌拉西林/他唑巴坦治疗中断，给予泼尼松龙治疗10天。患者临床症状改善，两周后实验室检查恢复正常。AGEP是哌拉西林/他唑巴坦治疗罕见的副作用，报道的病例较少。
