Borkosky Susana, Ponce de León Susana, Juárez Gabriela, Sierra Manuel González, Bardón Alicia
Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471, Tucumán 4000, Argentina.
Chem Biodivers. 2009 Apr;6(4):513-9. doi: 10.1002/cbdv.200800156.
Schistosomiasis is caused by parasitic flatworms of the genus Schistosoma, and some snails, particularly of the genus Biomphalaria (Planorbidae), are directly implicated in the transmission of the disease. Continuing with our investigations of bioactive plant constituents, we evaluated and report in the present article, the molluscicidal effects of 16 sesquiterpene lactones, as well as the commercial reagents tetrahydrofuran, furfural, and furfuryl alcohol, on an adult population of B. peregrina. The natural sesquiterpene lactones tested are characteristic constituents of species of the tribe Vernonieae, family Asteraceae. Compounds 1-3 and 7 came from a Bolivian collection of Vernonanthura pinguis, compounds 4 and 5 from an Argentine collection of Cyrtocymura cincta var. cincta, 6 was obtained from a Bolivian collection of Eirmocephala megaphylla, 8-14 from an Argentine collection of Centratherum punctatum ssp. punctatum, and compounds 15 and 16 were obtained by chemical derivatization from 5 and 14, respectively. Ten of the sesquiterpene lactones displayed moderate molluscicidal activity (LD50<100 microg/ml). Commercial reagents were inactive.
血吸虫病由血吸虫属的寄生扁虫引起，一些蜗牛，特别是双脐螺属（扁卷螺科）的蜗牛，直接参与了该疾病的传播。在继续我们对生物活性植物成分的研究中，我们评估并在本文中报告了16种倍半萜内酯以及商业试剂四氢呋喃、糠醛和糠醇对成年福寿螺的杀螺效果。所测试的天然倍半萜内酯是菊科斑鸠菊族植物的特征成分。化合物1 - 3和7来自玻利维亚采集的油叶斑鸠菊，化合物4和5来自阿根廷采集的环斑鸠菊变种环斑鸠菊，6从玻利维亚采集的大叶艾莫头草中获得，8 - 14来自阿根廷采集的尖叶刺苞菊亚种尖叶刺苞菊，化合物15和16分别通过对5和14进行化学衍生化得到。其中十种倍半萜内酯表现出中等杀螺活性（半数致死剂量<100微克/毫升）。商业试剂无活性。
