Alva Mariana, Popich Susana, Borkosky Susana, Cartagena Elena, Bardón Alicia
Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471, Tucumán 4000, Argentina.
Nat Prod Commun. 2012 Feb;7(2):245-8.
The essential oil of an Argentine collection of the annual herb Acanthospermum hispidum DC. (Asteraceae), which contains the sesquiterpenoids beta-caryophyllene (35.2%), alpha-bisabolol (11.4%), and germacrene D (11.1%) as major constituents, displayed molluscicidal effects on an adult population of Biomphalaria peregrina Orbigny (LD50 37.8 microg/mL) and produced alteration of the feeding and oviposition behavior of the polyphagous insect Spodoptera frugiperda Smith when incorporated in the larval diet at 250 microg/g. In addition, a selective antibacterial activity was observed against pathogenic strains of Staphylococcus aureus and Enterococcus faecalis (MICs 62.5 and 125 microg/mL), but was inactive at 125 microg/mL against three beneficial lactic acid bacteria. Synergistic interactions were further validated by FIC index determination of the combination of the antibiotics oxacillin and gentamicin and the essential oil on the four pathogenic strains evaluated.
对阿根廷一年生草本植物刺苞果（Acanthospermum hispidum DC.，菊科）提取物的精油进行了研究，其主要成分包括倍半萜类化合物β-石竹烯（35.2%）、α-红没药醇（11.4%）和杜松烯D（11.1%）。该精油对成年的三角帆蚌（Biomphalaria peregrina Orbigny）显示出杀螺活性（半数致死量为37.8微克/毫升），并且当以250微克/克的剂量添加到多食性昆虫草地贪夜蛾（Spodoptera frugiperda Smith）的幼虫饲料中时，会改变其取食和产卵行为。此外，该精油对金黄色葡萄球菌和粪肠球菌的致病菌株具有选择性抗菌活性（最低抑菌浓度分别为62.5和125微克/毫升），但在125微克/毫升的浓度下对三种有益乳酸菌无活性。通过测定抗生素苯唑西林和庆大霉素与该精油联合作用于四种评估的致病菌株的FIC指数，进一步验证了协同相互作用。
