Mizukami Shin, Takikawa Rika, Sugihara Fuminori, Shirakawa Masahiro, Kikuchi Kazuya
Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan.
Angew Chem Int Ed Engl. 2009;48(20):3641-3. doi: 10.1002/anie.200806328.
Dynamic duo: Magnetic resonance imaging (MRI) can visualize deep regions of living bodies, whereas fluorescence measurement offers excellent sensitivity. These methods thus offer signal enhancement potential for detecting enzyme activities. A dual-mode off/on probe to detect caspase-3 activity by fluorescence and (19)F MRI is presented.
磁共振成像（MRI）能够可视化活体的深部区域，而荧光测量具有出色的灵敏度。因此，这些方法在检测酶活性方面具有信号增强潜力。本文介绍了一种通过荧光和（19）F MRI检测半胱天冬酶-3活性的双模式开/关探针。
