Wicks Paul, MacPhee Graeme J A
Research and Development, PatientsLikeMe Inc., Cambridge, Massachusetts, USA.
Mov Disord. 2009 May 15;24(7):1085-8. doi: 10.1002/mds.22528.
Pathological gambling (PG) has been identified in Parkinson's disease (PD), but such gambling behaviors may also occur in amyotrophic lateral sclerosis (ALS). We sought to estimate the prevalence of PG amongst members of a web-based community, PatientsLikeMe.com. A survey was constructed, consisting of demographic information, the South Oaks Gambling Screen (SOGS), the K-6 measure of distress, and items related to motivation for gambling. Data were obtained from 236 ALS patients and 208 PD patients. Of the PD patients, 13% were classified as problem gamblers compared with 3% of ALS patients (chi(2) = 14.005, P <or= 0.001). PD patients reported thoughts about gambling to be more distressing, harder to resist and more outside their control than ALS patients. Thus, the higher prevalence of compulsive behavior in PD may relate to damaged reward pathways or medication rather than to the effects of living with a chronic progressive neurological disorder per se.
病理性赌博（PG）已在帕金森病（PD）中被发现，但这种赌博行为也可能发生在肌萎缩侧索硬化症（ALS）患者中。我们试图估计在线社区PatientsLikeMe.com成员中PG的患病率。构建了一项调查，包括人口统计学信息、南橡树赌博筛查量表（SOGS）、K-6苦恼量表以及与赌博动机相关的项目。数据来自236例ALS患者和208例PD患者。在PD患者中，13%被归类为问题赌徒，而ALS患者中这一比例为3%（χ² = 14.005，P≤0.001）。PD患者报告称，与ALS患者相比，他们对赌博的想法更令人苦恼、更难以抗拒且更不受自己控制。因此，PD中强迫行为的较高患病率可能与奖励通路受损或药物治疗有关，而非与患有慢性进行性神经疾病本身的影响有关。
