Mori T, Marmor M F, Miyoshi K, Tazawa Y
Department of Ophthalmology, Iwate Medical University, Morioka, Japan.
Doc Ophthalmol. 1991;76(4):315-22. doi: 10.1007/BF00142669.
In an attempt to simplify the recording technique in electrophysiologic evaluation of the retinal pigment epithelium, we combined the electro-oculographic light rise, hyperosmolarity and acetazolamide responses in a single recording session. Recordings were performed in six normal subjects and in seven patients with diabetic retinopathy or retinitis pigmentosa. In the patients with background diabetic retinopathy, the hyperosmolarity responses were slightly reduced, while the acetazolamide response and the light rise was normal. In the patients with proliferative diabetic retinopathy, the hyperosmolarity response and light rise were remarkably reduced, while the acetazolamide response was normal. In the patients with retinitis pigmentosa, the hyperosmolarity response and light rise were decreased, while the acetazolamide response was normal. Despite a small study population, we concluded that the clinical results from our combined recording protocol were essentially the same as those reported for each response separately. Because this recording technique simplifies electrophysiologic evaluation of the retinal pigment epithelium, it may help clarify the mechanisms or localization of retinochoroidal and pigment epithelial diseases.
为简化视网膜色素上皮细胞电生理评估中的记录技术，我们在一次记录过程中结合了眼电图光峰反应、高渗反应和乙酰唑胺反应。对6名正常受试者以及7名患有糖尿病性视网膜病变或色素性视网膜炎的患者进行了记录。在患有背景性糖尿病性视网膜病变的患者中，高渗反应略有降低，而乙酰唑胺反应和光峰反应正常。在患有增殖性糖尿病性视网膜病变的患者中，高渗反应和光峰反应显著降低，而乙酰唑胺反应正常。在患有色素性视网膜炎的患者中，高渗反应和光峰反应降低，而乙酰唑胺反应正常。尽管研究对象数量较少，但我们得出结论，我们的联合记录方案所得到的临床结果与分别报告的每种反应的结果基本相同。由于这种记录技术简化了视网膜色素上皮细胞的电生理评估，它可能有助于阐明视网膜脉络膜和色素上皮疾病的机制或定位。
