Jagtap Smita, Meganathan Kesavan, Wagh Vilas, Winkler Johannes, Hescheler Jürgen, Sachinidis Agapios
Center of Physiology and Pathophysiology, University of Cologne, Germany.
Curr Med Chem. 2009;16(12):1451-62. doi: 10.2174/092986709787909578.
Cancer and cardiovascular disease (CVD) chemoprevention can be achieved by the use of natural, synthetic, or biologic compounds to reverse, suppress, or prevent the development of diseases. Chemoprevention is a potential anti-cancer approach, which has reduced secondary effects in comparison to classical prophylaxis. Natural compounds such as flavonoids reduce oxidative stress, which is the most likely mechanism in the protective effects of these compounds. Even though the exact mechanisms of action are not well understood another central action mechanism of polyphenolic flavonoids seems to be an induction of apoptosis as demonstrated in numerous cellular systems. Moreover, flavonoids may modulate protein and lipid kinase signaling pathways. Understanding the mechanism of these natural products will contribute to the development of more specific preventive strategies against cancer and CVD. Much of the research in the field is focused on epigallocatechin-3-O-gallate (EGCG), quercetin and curcumin, which were found to have beneficial effects against cancer and CVD. We review the chemoprotective mechanisms through which these natural compounds exert their beneficial effects against cancer and CVDs.
癌症和心血管疾病（CVD）的化学预防可通过使用天然、合成或生物化合物来逆转、抑制或预防疾病的发展来实现。化学预防是一种潜在的抗癌方法，与传统预防相比，其副作用较小。黄酮类等天然化合物可降低氧化应激，这很可能是这些化合物发挥保护作用的机制。尽管确切的作用机制尚未完全明确，但多酚类黄酮的另一个核心作用机制似乎是诱导细胞凋亡，这在众多细胞系统中都得到了证实。此外，黄酮类化合物可能会调节蛋白质和脂质激酶信号通路。了解这些天然产物的作用机制将有助于开发更具针对性的癌症和心血管疾病预防策略。该领域的许多研究都集中在表没食子儿茶素-3-没食子酸酯（EGCG）、槲皮素和姜黄素上，它们被发现对癌症和心血管疾病具有有益作用。我们综述了这些天然化合物对癌症和心血管疾病发挥有益作用的化学保护机制。
