Sebag J, Reed W P, Williams R C
Infect Immun. 1977 Jun;16(3):947-54. doi: 10.1128/iai.16.3.947-954.1977.
Bacterial killing by serum alone and by polymorphonuclear )PMN) leukocytes was studied at 37 degrees C and compared with killing at 39 and 41 degrees C. The test organisms for serum killing were Staphylococcus aureus 502A (serum resistant) and Escherichia coli O14 (serum sensitive). The organisms used in PMN killing tests were Streptococcus pneumoniae type 29 and E. coli O86.S aureus was not killed by serum alone at any temperature. Changes in temperature did not affect the rate of serum killing of E. coli O14 for the first 60 min, but by 90 and 120 min there was a discrepancy with continued killing at 37 degrees C, but no further killing at 39 and 41 degrees C. PMN phagocytic killing of the pneumococcus was enhanced at 39 degrees C compared with 37 degrees C, and phagocytic killing of E. coli O86 was decreased at 41 degrees C when compared with 37 degrees C. Therefore, it appears that under certain circumstances fever may aid the host PMNs in destroying organisms, whereas under other circumstances it may interfere with such destruction.
在37摄氏度下研究了单独血清和多形核白细胞（PMN）对细菌的杀伤作用，并与39摄氏度和41摄氏度下的杀伤作用进行了比较。用于血清杀伤试验的受试微生物是金黄色葡萄球菌502A（血清抗性）和大肠杆菌O14（血清敏感）。用于PMN杀伤试验的微生物是29型肺炎链球菌和大肠杆菌O86。金黄色葡萄球菌在任何温度下都不会被单独血清杀死。在最初60分钟内，温度变化不影响血清对大肠杆菌O14的杀伤速率，但到90分钟和120分钟时，37摄氏度下继续有杀伤作用，而39摄氏度和41摄氏度下则没有进一步杀伤，出现了差异。与37摄氏度相比，39摄氏度时PMN对肺炎球菌的吞噬杀伤作用增强，与37摄氏度相比，41摄氏度时PMN对大肠杆菌O86的吞噬杀伤作用减弱。因此，在某些情况下，发热似乎有助于宿主PMN破坏微生物，而在其他情况下，发热可能会干扰这种破坏。
