Abe Akira, Hiraoka Miki, Shayman James A
University of Michigan Medical Center, Department of Internal Medicine, Division of Nephrology, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0676, USA.
Drug Metab Lett. 2007 Jan;1(1):49-53. doi: 10.2174/187231207779814292.
Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.
目前正在使用的许多治疗药物都是阳离子两亲物。这些阳离子两亲性药物（CADs）在人类和实验动物中会引发磷脂质病。最近的研究表明，CAD诱导的细胞磷脂质病与通过抑制溶酶体磷脂酶A2活性而导致的磷脂分解代谢受损有关。
