Salgado C M, Jardim P C B V, Teles F B G, Nunes M C
Division of Pediatric Nephrology, Federal University of Goiás (UFG), Goiânia, GO, Brazil.
Clin Nephrol. 2009 Apr;71(4):367-74. doi: 10.5414/cnp71367.
Low birth weight (LBW) is associated to an increased incidence of hypertension, renal and cardiovascular diseases in adulthood. The objective of this study was to evaluate possible changes in microalbuminuria (MA) and blood pressure (BP) in children with LBW.
The birth weight (BW) of 1,049 children between 8 and 11 years of age, enrolled in schools in the city of Goiânia/Brazil was investigated. Those in the LBW group (BW < or = 2.5 kg) were compared to a similar group with normal birth weight - NBW (BW > or = 3.0 kg). BP and 24-hour urine MA were evaluated. BW and prematurity (gestational age < 37 weeks) were obtained from the information contained in the children's card.
There were 34 children with LBW and 34 with NBW. No significant difference was found regarding age, sex, race, weight, height, BMI, and family history of hypertension or diabetes. Children with LBW presented higher systolic BP (p = 0.019) and more albumin in the 24-hour urine then children with NBW (p = 0.024).
We concluded that school children with LBW present with higher BP and more albumin excretion in the 24-hour urine. These findings can indicate presence of changes in both blood pressure and microalbuminuria in prepubertal children with low birth weight..
低出生体重（LBW）与成年期高血压、肾脏和心血管疾病发病率增加相关。本研究的目的是评估低出生体重儿童的微量白蛋白尿（MA）和血压（BP）可能发生的变化。
对巴西戈亚尼亚市学校中1049名8至11岁儿童的出生体重（BW）进行了调查。将低出生体重组（BW≤2.5kg）与出生体重正常的类似组——正常出生体重组（NBW，BW≥3.0kg）进行比较。评估了血压和24小时尿微量白蛋白。出生体重和早产情况（胎龄<37周）从儿童卡片中的信息获取。
有34名低出生体重儿童和34名正常出生体重儿童。在年龄、性别、种族、体重、身高、BMI以及高血压或糖尿病家族史方面未发现显著差异。低出生体重儿童的收缩压更高（p = 0.019），24小时尿中的白蛋白含量也高于正常出生体重儿童（p = 0.024）。
我们得出结论，低出生体重的学龄儿童收缩压更高，24小时尿中白蛋白排泄更多。这些发现可能表明低出生体重的青春期前儿童血压和微量白蛋白尿均发生了变化。
