Stringer M R, Moghissi K, Dixon K
Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Woodhouse Lane, Leeds LS29JT, UK.
Photodiagnosis Photodyn Ther. 2008 Jun;5(2):148-52. doi: 10.1016/j.pdpdt.2008.06.002. Epub 2008 Jul 7.
We assess the sensitivity of autofluorescence bronchoscopy (AFB) compared to that of white light bronchoscopy (WLB) for identification of pre-invasive neoplastic changes of bronchial mucosa in asymptomatic heavy smokers. WLB was performed using a standard flexible fibre-optic bronchoscope, and AFB carried out using the Xillix LIFE Lung((R)) system. Positive AFB images were indicated in the bronchial tree from 51 of the 93 subjects in the study. Biopsies showed epithelial abnormalities in 27 (15 metaplasia, 12 inflammatory changes) of these. WLB showed abnormality in 1 subject but with no pathological changes revealed by cyto-histology. Therefore, the sensitivity of AFB to metaplasia was 75% compared to zero for WLB. AFB yields positive predictive values for metaplastic and overall mucosal changes of 29.4% and 52.9%, respectively. In summary, over 16% of asymptomatic smokers had metaplastic changes in their bronchial mucosa, and AFB proved more sensitive in revealing early changes than WLB.
我们评估了自体荧光支气管镜检查（AFB）与白光支气管镜检查（WLB）相比，在识别无症状重度吸烟者支气管黏膜癌前肿瘤变化方面的敏感性。使用标准的柔性纤维支气管镜进行WLB，使用Xillix LIFE Lung((R))系统进行AFB。该研究中93名受试者中有51名的支气管树显示AFB图像呈阳性。活检显示其中27例（15例化生，12例炎症改变）存在上皮异常。WLB显示1名受试者有异常，但细胞组织学未发现病理变化。因此，AFB对化生的敏感性为75%，而WLB为零。AFB对化生和总体黏膜变化的阳性预测值分别为29.4%和52.9%。总之，超过16%的无症状吸烟者支气管黏膜有化生改变，并且AFB在揭示早期变化方面比WLB更敏感。
