Eisendle K, Zelger B
Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria.
G Ital Dermatol Venereol. 2009 Apr;144(2):157-71.
The known spectrum of skin manifestations in cutaneous Lyme disease is continuously expanding and can not be regarded as completed. Besides the classical manifestations of cutaneous borreliosis like erythema (chronicum) migrans, borrelial lymphocytoma and acrodermatitis chronica atrophicans evidence is growing that at least in part also other skin manifestations, especially morphea, lichen sclerosus and cases of cutaneous B-cell lymphoma are causally related to infections with Borrelia. Also granuloma annulare and interstitial granulomatous dermatitis might be partly caused by Borrelia burgdorferi or similar strains. There are also single reports of other skin manifestations to be associated with borrelial infections like cutaneous sarcoidosis, necrobiosis lipoidica and necrobiotic xanthogranuloma. In addition, as the modern chameleon of dermatology, cutaneous borreliosis, especially borrelial lymphocytoma, mimics other skin conditions, as has been shown for erythema annulare centrifugum or lymphocytic infiltration (Jessner Kanof) of the skin.
皮肤型莱姆病已知的皮肤表现谱在不断扩大，不能认为已完整。除了皮肤型疏螺旋体病的经典表现，如游走性（慢性）红斑、疏螺旋体淋巴细胞瘤和萎缩性慢性肢端皮炎外，越来越多的证据表明，至少部分其他皮肤表现，特别是硬斑病、硬化性苔藓和皮肤B细胞淋巴瘤病例与伯氏疏螺旋体感染存在因果关系。环状肉芽肿和间质性肉芽肿性皮炎也可能部分由伯氏疏螺旋体或类似菌株引起。也有个别报告称其他皮肤表现与疏螺旋体感染有关，如皮肤结节病、类脂质渐进性坏死和坏死性黄色肉芽肿。此外，作为皮肤科的现代变色龙，皮肤型疏螺旋体病，尤其是疏螺旋体淋巴细胞瘤，会模仿其他皮肤疾病，如离心性环状红斑或皮肤淋巴细胞浸润（杰斯纳 - 卡诺夫病）所示。
