Teicher Martin H, Samson Jacqueline A, Polcari Ann, Andersen Susan L
Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA.
J Clin Psychiatry. 2009 May;70(5):684-91. doi: 10.4088/jcp.08m04235. Epub 2009 Apr 7.
Depression is the most common adult outcome of exposure to childhood sexual abuse (CSA). In this study, we retrospectively assessed the length of time from initial abuse exposure to onset of a major depressive episode.
A community-based survey of childhood experiences in 564 young adults aged 18 to 22 years, conducted between 1997 and 2001, identified 29 right-handed female subjects with CSA but no other exposure to trauma. Subjects were interviewed for lifetime history and age at onset of Axis I disorders using the Structured Clinical Interview for DSM-IV Axis I Disorders.
Sixty-two percent (N = 18) of the sexual abuse sample met full lifetime criteria for major depressive disorder. Episodes of depression emerged a mean +/- SD of 9.2 +/- 3.6 years after onset of exposure to sexual abuse. Mean survival time from onset of abuse to onset of depression for the entire sample was 11.47 years (95% CI = 9.80 to 13.13 years). There was a surge in new cases between 12 and 15 years of age. Mean +/- SD time to onset of posttraumatic stress disorder was 8.0 +/- 3.9 years.
Exposure to CSA appears to sensitize women to the development of depression and to shift age at onset to early adolescence. Findings from this formative study suggest that clinicians should not interpret the absence of symptoms at the time of CSA as a sign of resilience. Continued monitoring of victims of CSA as they pass through puberty is recommended. Reasons for the time lag between CSA and depression are proposed along with potential strategies for early intervention.
抑郁症是童年期遭受性虐待(CSA)后最常见的成人后果。在本研究中,我们回顾性评估了从首次遭受虐待到重度抑郁发作开始的时间长度。
1997年至2001年间对564名18至22岁的年轻人进行了一项基于社区的童年经历调查,确定了29名右利手女性CSA患者,但无其他创伤暴露经历。使用《精神疾病诊断与统计手册》第四版轴I障碍的结构化临床访谈,对受试者进行了关于一生病史和轴I障碍发病年龄的访谈。
62%(N = 18)的性虐待样本符合重度抑郁症的终生全部标准。抑郁发作出现在遭受性虐待开始后的平均±标准差为9.2±3.6年。整个样本从虐待开始到抑郁发作的平均生存时间为11.47年(95%可信区间 = 9.80至13.13年)。12至15岁之间新病例激增。创伤后应激障碍发作的平均±标准差时间为8.0±3.9年。
遭受CSA似乎使女性对抑郁症的发展敏感,并将发病年龄提前到青春期早期。这项形成性研究的结果表明,临床医生不应将CSA时无症状解释为恢复力的标志。建议在CSA受害者进入青春期时持续进行监测。提出了CSA与抑郁症之间时间间隔的原因以及早期干预的潜在策略。