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Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development.童年期性虐待对大脑区域发育影响中敏感期的初步证据。
J Neuropsychiatry Clin Neurosci. 2008 Summer;20(3):292-301. doi: 10.1176/jnp.2008.20.3.292.
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Stress, sensitive periods and maturational events in adolescent depression.青少年抑郁症中的压力、敏感期和成熟事件。
Trends Neurosci. 2008 Apr;31(4):183-91. doi: 10.1016/j.tins.2008.01.004. Epub 2008 Mar 10.
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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.成年齿状回中运动诱导神经发生的体内关联。
Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5638-43. doi: 10.1073/pnas.0611721104. Epub 2007 Mar 20.
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The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes.转录因子神经生长因子诱导蛋白a介导表观遗传编程:通过即早基因改变表观遗传标记。
J Neurosci. 2007 Feb 14;27(7):1756-68. doi: 10.1523/JNEUROSCI.4164-06.2007.
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Sticks, stones, and hurtful words: relative effects of various forms of childhood maltreatment.棍棒、石头和伤人的话语:各种形式童年虐待的相对影响
Am J Psychiatry. 2006 Jun;163(6):993-1000. doi: 10.1176/ajp.2006.163.6.993.
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Hippocampal and amygdalar volumes in dissociative identity disorder.分离性身份障碍中的海马体和杏仁核体积
Am J Psychiatry. 2006 Apr;163(4):630-6. doi: 10.1176/ajp.2006.163.4.630.
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Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.通过DNA甲基化对压力反应进行环境编程:在动态环境与固定基因组之间的界面上的生命历程
Dialogues Clin Neurosci. 2005;7(2):103-23. doi: 10.31887/DCNS.2005.7.2/mmeaney.
8
Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.全国共病调查复制研究中 DSM-IV 障碍的终生患病率和发病年龄分布
Arch Gen Psychiatry. 2005 Jun;62(6):593-602. doi: 10.1001/archpsyc.62.6.593.
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Social supports and serotonin transporter gene moderate depression in maltreated children.社会支持和血清素转运体基因可缓解受虐待儿童的抑郁症状。
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17316-21. doi: 10.1073/pnas.0404376101. Epub 2004 Nov 24.
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Adverse childhood experiences and the risk of depressive disorders in adulthood.童年不良经历与成年期抑郁症风险
J Affect Disord. 2004 Oct 15;82(2):217-25. doi: 10.1016/j.jad.2003.12.013.

青少年样本中儿童期性虐待开始至成年早期出现抑郁症之间的时间间隔:一项回顾性临床报告。

Length of time between onset of childhood sexual abuse and emergence of depression in a young adult sample: a retrospective clinical report.

作者信息

Teicher Martin H, Samson Jacqueline A, Polcari Ann, Andersen Susan L

机构信息

Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA.

出版信息

J Clin Psychiatry. 2009 May;70(5):684-91. doi: 10.4088/jcp.08m04235. Epub 2009 Apr 7.

DOI:10.4088/jcp.08m04235
PMID:19358787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4266432/
Abstract

OBJECTIVE

Depression is the most common adult outcome of exposure to childhood sexual abuse (CSA). In this study, we retrospectively assessed the length of time from initial abuse exposure to onset of a major depressive episode.

METHOD

A community-based survey of childhood experiences in 564 young adults aged 18 to 22 years, conducted between 1997 and 2001, identified 29 right-handed female subjects with CSA but no other exposure to trauma. Subjects were interviewed for lifetime history and age at onset of Axis I disorders using the Structured Clinical Interview for DSM-IV Axis I Disorders.

RESULTS

Sixty-two percent (N = 18) of the sexual abuse sample met full lifetime criteria for major depressive disorder. Episodes of depression emerged a mean +/- SD of 9.2 +/- 3.6 years after onset of exposure to sexual abuse. Mean survival time from onset of abuse to onset of depression for the entire sample was 11.47 years (95% CI = 9.80 to 13.13 years). There was a surge in new cases between 12 and 15 years of age. Mean +/- SD time to onset of posttraumatic stress disorder was 8.0 +/- 3.9 years.

CONCLUSIONS

Exposure to CSA appears to sensitize women to the development of depression and to shift age at onset to early adolescence. Findings from this formative study suggest that clinicians should not interpret the absence of symptoms at the time of CSA as a sign of resilience. Continued monitoring of victims of CSA as they pass through puberty is recommended. Reasons for the time lag between CSA and depression are proposed along with potential strategies for early intervention.

摘要

目的

抑郁症是童年期遭受性虐待(CSA)后最常见的成人后果。在本研究中,我们回顾性评估了从首次遭受虐待到重度抑郁发作开始的时间长度。

方法

1997年至2001年间对564名18至22岁的年轻人进行了一项基于社区的童年经历调查,确定了29名右利手女性CSA患者,但无其他创伤暴露经历。使用《精神疾病诊断与统计手册》第四版轴I障碍的结构化临床访谈,对受试者进行了关于一生病史和轴I障碍发病年龄的访谈。

结果

62%(N = 18)的性虐待样本符合重度抑郁症的终生全部标准。抑郁发作出现在遭受性虐待开始后的平均±标准差为9.2±3.6年。整个样本从虐待开始到抑郁发作的平均生存时间为11.47年(95%可信区间 = 9.80至13.13年)。12至15岁之间新病例激增。创伤后应激障碍发作的平均±标准差时间为8.0±3.9年。

结论

遭受CSA似乎使女性对抑郁症的发展敏感,并将发病年龄提前到青春期早期。这项形成性研究的结果表明,临床医生不应将CSA时无症状解释为恢复力的标志。建议在CSA受害者进入青春期时持续进行监测。提出了CSA与抑郁症之间时间间隔的原因以及早期干预的潜在策略。