使用N-羟乙酰神经氨酸亚磷酸供体进行唾液酸化以合成含Neu5Gc的聚糖。
Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans.
作者信息
Hanashima Shinya, Tomiya Taku, Ishikawa Daichi, Akai Shoji, Sato Ken-ichi
机构信息
Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama, Japan.
出版信息
Carbohydr Res. 2009 May 26;344(8):959-65. doi: 10.1016/j.carres.2009.03.004. Epub 2009 Mar 11.
Efficient sialylations using N-glycolylneuraminic acid (Neu5Gc) phosphite donors having an acetyl or benzyl group on the glycolyl moiety are described in the synthesis of Neu5Gc-containing glycans. Both phosphite donors 1 and 2 were readily coupled with primary and secondary acceptor alcohols in propionitrile at -78 degrees C to provide the desired glycosides with good alpha-selectivities.
在含N-羟乙酰神经氨酸（Neu5Gc）聚糖的合成中，描述了使用在羟乙酰部分带有乙酰基或苄基的N-羟乙酰神经氨酸（Neu5Gc）亚磷酸酯供体进行高效唾液酸化反应。亚磷酸酯供体1和2在-78℃下均能很容易地与丙腈中的伯醇和仲醇受体偶联，以良好的α-选择性提供所需的糖苷。
Zotero 插件