含 C5 多样化唾液酸的唾液糖的平行酶促合成。
Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid.
机构信息
Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
出版信息
Bioorg Med Chem Lett. 2009 Oct 15;19(20):5869-71. doi: 10.1016/j.bmcl.2009.08.078. Epub 2009 Aug 26.
Abstract
A convenient chemoenzymatic strategy for synthesizing sialosides containing a C5-diversified sialic acid was developed. The alpha2,3- and alpha2,6-linked sialosides containing a 5-azido neuraminic acid synthesized by a highly efficient one-pot three-enzyme approach were converted to C5''-amino sialosides, which were used as common intermediates for chemical parallel synthesis to quickly generate a series of sialosides containing various sialic acid forms.
摘要
开发了一种方便的酶促化学策略，用于合成含有 C5 多样化唾液酸的唾液酸苷。通过高效的一锅三酶方法合成的含有 5-叠氮神经氨酸的α2,3-和α2,6-连接的唾液酸苷被转化为 C5''-氨基唾液酸苷，它们可用作化学平行合成的通用中间体，以快速生成一系列含有各种唾液酸形式的唾液酸苷。
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