Soltan Muna, Smiler Dennis, Choi Jennifer H
Private Practice, 9402 Magnolia Avenue, Riverside, CA 92503, USA.
Implant Dent. 2009 Apr;18(2):132-41. doi: 10.1097/ID.0b013e3181990e75.
Bone regeneration requires an orchestrated interaction between various cells and other biological components. The synthesis of bone matrix with the release of cellular cytokines and growth factors facilitates and regulates cell growth. This leads to the maturation of bone that can support functional implants. Bone-marrow aspirate is a rich source of cells, cytokines, and growth factors needed for bone formation. Harvesting the marrow from the anterior iliac crest is a simple, safe, and cost-effective procedure. Mixing it with a resorbable scaffold and transplanting it to a site can predictably enhance bone regeneration. This article explores the anatomy of the bone marrow and describes the necessary elements for successful bone grafts, such as cells, bone matrix, and cellular regulators (both soluble and insoluble).
骨再生需要多种细胞与其他生物成分之间进行协调的相互作用。骨基质的合成以及细胞因子和生长因子的释放促进并调节细胞生长。这会导致能够支撑功能性植入物的骨成熟。骨髓抽吸物是骨形成所需的细胞、细胞因子和生长因子的丰富来源。从髂前嵴采集骨髓是一种简单、安全且经济高效的操作。将其与可吸收支架混合并移植到某个部位可以预期地增强骨再生。本文探讨了骨髓的解剖结构，并描述了成功进行骨移植所需的要素，如细胞、骨基质和细胞调节因子（包括可溶性和不可溶性的）。
