Hamilton N, Ashton M L, Ianuzzo C D
Department of Physical Education, York University, Toronto, Ontario, Canada.
Experientia. 1991 Oct 15;47(10):1070-2. doi: 10.1007/BF01923345.
Morphological characteristics of myocardial ventricular myocytes have been evaluated from 5 mammalian orders with resting heart rates ranging from 51 to 475 bpm. The purpose was to determine if morphological characteristics of the myocardia are related to the functional demand imposed on the cell as represented by the resting heart rate. Cell size is a constant among mammals of different sizes which have different physiological demands. In contrast, there is more mitochondrial area and less myofibrillar area per cell in animals with rapidly beating hearts than in animals with slower heart rates. Additionally, the mean cross sectional area of individual myofibrils is 30% larger in the cow as compared to the mouse. These findings combined with our previous studies indicate that the different functional requirements of myocardia from different mammalian orders are satisfied by intracellular adaptations of both a structural and biochemical nature.
已对5个哺乳动物目具有51至475次/分钟静息心率的心室肌细胞的形态特征进行了评估。目的是确定心肌的形态特征是否与静息心率所代表的施加于细胞的功能需求相关。细胞大小在具有不同生理需求的不同大小哺乳动物中是恒定的。相比之下，心率快的动物比心率慢的动物每个细胞的线粒体面积更大，肌原纤维面积更小。此外，与小鼠相比，牛的单个肌原纤维的平均横截面积大30%。这些发现与我们之前的研究相结合表明，不同哺乳动物目的心肌的不同功能需求通过结构和生化性质的细胞内适应性得到满足。
