将心脏中的线粒体体积与体重进行比例缩放。

Scaling mitochondrial volume in heart to body mass.

作者信息

Hoppeler H, Lindstedt S L, Claassen H, Taylor C R, Mathieu O, Weibel E R

出版信息

Respir Physiol. 1984 Feb;55(2):131-7. doi: 10.1016/0034-5687(84)90018-5.

Abstract

The heart mass was measured and the volume density of mitochondria, VV(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb0 .970 whereas VV(mt,f) scaled as Mb-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb0 .927 (V(mt) = VV(mt,f) x Vh). The volume of heart mitochondria was found to scale disproportionately to VO2max ( Mb0 .75) but in proportion to resting cardiac work rate ( Mb0 .9).

摘要

测量了11种哺乳动物（从体重3克的鼩鼱到920千克的牛）的心脏质量，并通过形态计量学方法估计了线粒体的体积密度VV(mt,f)。发现心肌质量或体积（Vh）与体重（Mb）的0.970次幂呈比例关系，而VV(mt,f)与体重的 -0.044次幂呈比例关系。因此，心脏中线粒体的总体积V(mt)与体重的0.927次幂呈比例关系（V(mt)=VV(mt,f)×Vh）。研究发现，心脏线粒体的体积与最大摄氧量（VO2max，与体重的0.75次幂呈比例关系）不成比例，但与静息心脏工作率（与体重的0.9次幂呈比例关系）成比例。