Adamson Adewole S, Collins Kalonji, Laurence Arian, O'Shea John J
Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Curr Opin Immunol. 2009 Apr;21(2):161-6. doi: 10.1016/j.coi.2009.03.013. Epub 2009 Apr 9.
Recently, our understanding of helper/effector T cell differentiation has changed significantly. New subsets of T cells continue to be recognized, including Th17, Treg, and Th9 cells. In addition, the signaling pathways that contribute to their generation continue to be refined. It has become clear that STAT family proteins play a major role in these 'new' T cell fates, along with their critical role in more classical fates. Importantly, genetic studies implicate STATs in autoimmune and primary immunodeficiency diseases in humans. Focusing on how STATs work in concert with other transcription factors will hopefully provide a better mechanistic understanding of the pathogenesis of various autoimmune diseases.
最近,我们对辅助/效应T细胞分化的理解发生了显著变化。新的T细胞亚群不断被识别出来,包括Th17、Treg和Th9细胞。此外,促成它们产生的信号通路也在不断完善。很明显,STAT家族蛋白在这些“新的”T细胞命运中发挥着主要作用,同时在更经典的命运中也起着关键作用。重要的是,遗传学研究表明STATs与人类自身免疫性疾病和原发性免疫缺陷病有关。关注STATs如何与其他转录因子协同作用,有望为各种自身免疫性疾病的发病机制提供更好的机制性理解。