桑叶中的两种新查尔酮

Two new chalcones from leaves of Morus alba L.

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Fitoterapia. 2010 Sep;81(6):614-6. doi: 10.1016/j.fitote.2010.03.005. Epub 2010 Mar 6.

DOI:10.1016/j.fitote.2010.03.005

PMID:20211228

Abstract

Two new chalcone derivatives named morachalcones B and C (1 and 2) were isolated from the leaves of Morus alba L. Their structures were elucidated by spectroscopic analysis. Morachalcones B (1) and C (2) represent two examples of chalcones having unusual furan rings which are formed by cyclization between C-alpha-OH and C-2-OH. Compounds 1 and 2 displayed only moderate cytotoxic activity against HCT-8 and BGC823 human cancer cell lines.

摘要

从桑树叶中分离得到了两个新的查尔酮衍生物，命名为morachalcones B 和 C（1 和 2）。通过光谱分析阐明了它们的结构。Morachalcones B（1）和 C（2）代表了两个具有不寻常呋喃环的查尔酮的例子，这些呋喃环是通过 C-α-OH 和 C-2-OH 之间的环化形成的。化合物 1 和 2 对 HCT-8 和 BGC823 人癌细胞系仅表现出中等的细胞毒性活性。