来自矮地紫堇根的细胞毒二萜醌甲醚。

Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea.

机构信息

Organic Chemistry Division-II, Indian Institute of Chemical Technology, Hyderabad, India.

出版信息

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4581-4. doi: 10.1016/j.bmcl.2011.05.109. Epub 2011 Jun 12.

DOI:10.1016/j.bmcl.2011.05.109

Abstract

Two new diterpenoid quinonemethides (1 and 2) along with two known compounds (3 and 4) were isolated from the hexane and ethyl acetate extracts of root nodules of Pygmacopremna herbacea. The structures of the new compounds were established by spectroscopic data interpretation. Single crystal X-ray diffraction analysis confirmed the structure of 1. The cytotoxic activities of these compounds were evaluated against A 549, HEPG2, MCF-7, PC-3 and HELA cancer cell lines. Compounds 4, 2 and 1 were shown very good cytotoxic activity.

摘要

从 Pygmacopremna herbacea 的根瘤的正己烷和乙酸乙酯提取物中分离得到两个新的二萜醌甲醚（1 和 2）以及两个已知化合物（3 和 4）。通过光谱数据分析确定了新化合物的结构。单晶 X 射线衍射分析证实了 1 的结构。对这些化合物进行了针对 A549、HEPG2、MCF-7、PC-3 和 HELA 癌细胞系的细胞毒性活性评估。化合物 4、2 和 1 表现出非常好的细胞毒性活性。