Fattal Elias, Barratt Gillian
Univ Paris Sud 11, UMR 8612, Châtenay-Malabry, F-92290, France.
Br J Pharmacol. 2009 May;157(2):179-94. doi: 10.1111/j.1476-5381.2009.00148.x. Epub 2009 Apr 2.
Antisense oligonucleotides and small interfering RNA have enormous potential for the treatment of a number of diseases, including cancer. However, several impediments to their widespread use as drugs still have to be overcome: in particular their lack of stability in physiological fluids and their poor penetration into cells. Association with or encapsulation within nano- and microsized drug delivery systems could help to solve these problems. In this review, we describe the progress that has been made using delivery systems composed of natural or synthetic polymers in the form of complexes, nanoparticles or microparticles.
反义寡核苷酸和小干扰RNA在治疗包括癌症在内的多种疾病方面具有巨大潜力。然而，要将它们广泛用作药物仍需克服若干障碍：特别是它们在生理流体中缺乏稳定性以及难以穿透细胞。与纳米和微米级药物递送系统结合或封装在其中可能有助于解决这些问题。在本综述中，我们描述了使用由天然或合成聚合物以复合物、纳米颗粒或微粒形式组成的递送系统所取得的进展。
