用于反义寡核苷酸和小干扰RNA递送的纳米技术与控释系统。
Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA.
作者信息
Fattal Elias, Barratt Gillian
机构信息
Univ Paris Sud 11, UMR 8612, Châtenay-Malabry, F-92290, France.
出版信息
Br J Pharmacol. 2009 May;157(2):179-94. doi: 10.1111/j.1476-5381.2009.00148.x. Epub 2009 Apr 2.
Abstract
Antisense oligonucleotides and small interfering RNA have enormous potential for the treatment of a number of diseases, including cancer. However, several impediments to their widespread use as drugs still have to be overcome: in particular their lack of stability in physiological fluids and their poor penetration into cells. Association with or encapsulation within nano- and microsized drug delivery systems could help to solve these problems. In this review, we describe the progress that has been made using delivery systems composed of natural or synthetic polymers in the form of complexes, nanoparticles or microparticles.
摘要
反义寡核苷酸和小干扰RNA在治疗包括癌症在内的多种疾病方面具有巨大潜力。然而，要将它们广泛用作药物仍需克服若干障碍：特别是它们在生理流体中缺乏稳定性以及难以穿透细胞。与纳米和微米级药物递送系统结合或封装在其中可能有助于解决这些问题。在本综述中，我们描述了使用由天然或合成聚合物以复合物、纳米颗粒或微粒形式组成的递送系统所取得的进展。
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Pharm Res. 2008 Dec;25(12):2972-82. doi: 10.1007/s11095-008-9693-1. Epub 2008 Aug 16.
2
Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles.通过纳米颗粒联合疫苗接种和反义寡核苷酸递送进行脑肿瘤治疗。
J Neuroimmunol. 2008 Mar;195(1-2):21-7. doi: 10.1016/j.jneuroim.2007.12.005. Epub 2008 Mar 4.
3
siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma.针对ret/PTC1连接癌基因的小干扰RNA纳米制剂在甲状腺乳头状癌体内模型中具有高效性。
Nucleic Acids Res. 2008 Jan;36(1):e2. doi: 10.1093/nar/gkm1094. Epub 2007 Dec 13.
4
Impact of PAMAM G2 and G6 dendrimers on bovine serum albumin (fatty acids free and loaded with different fatty acids).聚酰胺-胺型（PAMAM）G2和G6树枝状大分子对牛血清白蛋白（游离脂肪酸及负载不同脂肪酸的牛血清白蛋白）的影响。
Colloids Surf B Biointerfaces. 2008 May 1;63(1):27-33. doi: 10.1016/j.colsurfb.2007.10.020. Epub 2007 Nov 4.
5
Importance of size-to-charge ratio in construction of stable and uniform nanoscale RNA/dendrimer complexes.尺寸与电荷比在构建稳定且均匀的纳米级RNA/树枝状聚合物复合物中的重要性。
Org Biomol Chem. 2007 Nov 21;5(22):3674-81. doi: 10.1039/b711242d. Epub 2007 Oct 2.
6
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Biomaterials. 2008 Feb;29(4):506-12. doi: 10.1016/j.biomaterials.2007.10.003. Epub 2007 Oct 24.
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Biotechnol Bioeng. 2008 Mar 1;99(4):975-85. doi: 10.1002/bit.21668.
8
Tumor-targeted delivery of siRNA by self-assembled nanoparticles.通过自组装纳米颗粒实现siRNA的肿瘤靶向递送。
Mol Ther. 2008 Jan;16(1):163-9. doi: 10.1038/sj.mt.6300323. Epub 2007 Oct 9.
9
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging.通过多模态体内成像测量肿瘤特异性靶向对siRNA纳米颗粒生物分布和疗效的影响。
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15549-54. doi: 10.1073/pnas.0707461104. Epub 2007 Sep 17.
10
Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system.树枝状聚合物修饰的磁性纳米颗粒提高基因递送系统的效率。
Cancer Res. 2007 Sep 1;67(17):8156-63. doi: 10.1158/0008-5472.CAN-06-4762.
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