胰腺移植对尿毒症1型（胰岛素依赖型）糖尿病患者预期寿命、肾功能及生活质量的影响。

Effect of pancreas transplantation on life expectancy, kidney function and quality of life in uraemic type 1 (insulin-dependent) diabetic patients.

作者信息

Secchi A, Di Carlo V, Martinenghi S, La Rocca E, Caldara R, Spotti D, Slaviero G, Staudacher C, Ferrari G, Pozza G

机构信息

Department of Internal Medicine, Istituto Scientifico San Raffaele, Milan, Italy.

出版信息

Diabetologia. 1991 Aug;34 Suppl 1:S141-4. doi: 10.1007/BF00587642.

DOI:10.1007/BF00587642

PMID:1936682

Abstract

The aim of our study was to evaluate the effects of haemodialysis, kidney transplantation and simultaneous kidney and pancreas transplantation on survival of diabetic subjects and on kidney function. 40 Type 1 (insulin-dependent) diabetic patients received a kidney transplantation: in 31 cases the kidney was transplanted simultaneously to a pancreas graft from the same donor (KP group), while in 9 cases the pancreas was not available (K group). 44 uraemic Type 1 (insulin-dependent) diabetic patients on dialysis and in waiting list for kidney transplantation, constituted the control group (HD group). Patient survival rate 1, 3 and 5 years following transplantation was better in KP group (93%, 89%, 89%, respectively) and in K group (88%, 88%, 73%, respectively) and in HD group (88%, 62%, 51%, respectively). Kidney graft survival at 1, 3 and 5 years post-transplant was better in KP group (93%, 72%, 72%, respectively) than in K group (76%, 61%, 31%, respectively). 1 year after transplantation, patients of the KP group who had lost the pancreas for technical reasons (thrombosis) were included in the K group so as to evaluate the effect of the transplanted pancreas on long-term patient and kidney survival. Patient survival rate in the KP group (17 patients) at 2 and 4 years was 100%, while at the same intervals it was 78% in the K group (13 patients). Kidney graft function rate at 2 and 4 years was 93% in the KP group (17 grafts) and 54% and 27% respectively in the K group (14 grafts).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

我们研究的目的是评估血液透析、肾移植以及肾胰联合移植对糖尿病患者生存率和肾功能的影响。40例1型（胰岛素依赖型）糖尿病患者接受了肾移植：31例患者同时接受了来自同一供体的胰腺移植（肾胰联合移植组），而9例患者未接受胰腺移植（肾移植组）。44例接受透析且在等待肾移植的尿毒症1型（胰岛素依赖型）糖尿病患者构成了对照组（血液透析组）。肾胰联合移植组（移植后1年、3年和5年的患者生存率分别为93%、89%、89%）、肾移植组（分别为88%、88%、73%）和血液透析组（分别为88%、62%、51%）中，移植后1年、3年和5年的患者生存率均较高。肾胰联合移植组移植后1年、3年和5年的肾移植存活率（分别为93%、72%、72%）高于肾移植组（分别为76%、61%、31%）。移植1年后，因技术原因（血栓形成）失去胰腺的肾胰联合移植组患者被纳入肾移植组，以评估移植胰腺对患者长期生存和肾存活的影响。肾胰联合移植组（17例患者）2年和4年的患者生存率为100%，而肾移植组（13例患者）在相同时间段的生存率为78%。肾胰联合移植组（17个移植肾）2年和4年的肾移植功能率为93%，肾移植组（14个移植肾）分别为54%和27%。（摘要截选至250词）