Ruiz Jonatan R, Sui Xuemei, Lobelo Felipe, Lee Duck-Chul, Morrow James R, Jackson Allen W, Hébert James R, Matthews Charles E, Sjöström Michael, Blair Steven N
Department of Biosciences and Nutrition, Karolinska Institutet, Sweden.
Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1468-76. doi: 10.1158/1055-9965.EPI-08-1075. Epub 2009 Apr 14.
We examined the associations between muscular strength, markers of overall and central adiposity, and cancer mortality in men.
A prospective cohort study including 8,677 men ages 20 to 82 years followed from 1980 to 2003. Participants were enrolled in The Aerobics Centre Longitudinal Study, the Cooper Institute in Dallas, Texas. Muscular strength was quantified by combining 1-repetition maximal measures for leg and bench presses. Adiposity was assessed by body mass index (BMI), percent body fat, and waist circumference.
Cancer death rates per 10,000 person-years adjusted for age and examination year were 17.5, 11.0, and 10.3 across incremental thirds of muscular strength (P = 0.001); 10.9, 13.4, and 20.1 across BMI groups of 18.5-24.9, 25.0-29.9, and > or =30 kg/m(2), respectively (P = 0.008); 11.6 and 17.5 for normal (<25%) and high percent body fat (> or =25%), respectively (P = 0.006); and 12.2 and 16.7 for normal (< or =102 cm) and high waist circumference (>102 cm), respectively (P = 0.06). After adjusting for additional potential confounders, hazard ratios (95% confidence intervals) were 1.00 (reference), 0.65 (0.47-0.90), and 0.61 (0.44-0.85) across incremental thirds of muscular strength, respectively (P = 0.003 for linear trend). Further adjustment for BMI, percent body fat, waist circumference, or cardiorespiratory fitness had little effect on the association. The associations of BMI, percent body fat, or waist circumference with cancer mortality did not persist after further adjusting for muscular strength (all P > or = 0.1).
Higher levels of muscular strength are associated with lower cancer mortality risk in men, independent of clinically established measures of overall and central adiposity, and other potential confounders.
我们研究了男性肌肉力量、总体及中心性肥胖标志物与癌症死亡率之间的关联。
一项前瞻性队列研究，纳入了1980年至2003年期间随访的8677名年龄在20至82岁的男性。参与者来自德克萨斯州达拉斯市库珀研究所的有氧运动中心纵向研究。通过结合腿部和卧推的1次重复最大重量测量来量化肌肉力量。通过体重指数（BMI）、体脂百分比和腰围评估肥胖程度。
按年龄和检查年份调整后的每10000人年癌症死亡率，在肌肉力量递增的三个三分位数中分别为17.5、11.0和10.3（P = 0.001）；在BMI分别为18.5 - 24.9、25.0 - 29.9和≥30 kg/m²的组中分别为10.9、13.4和20.1（P = 0.008）；正常体脂百分比（<25%）和高体脂百分比（≥25%）的分别为11.6和17.5（P = 0.006）；正常腰围（≤102 cm）和高腰围（>102 cm）的分别为12.2和16.7（P = 0.06）。在调整了其他潜在混杂因素后，肌肉力量递增的三个三分位数对应的风险比（95%置信区间）分别为1.00（参考值）、0.65（0.47 - 0.90）和0.61（0.44 - 0.85）（线性趋势P = 0.003）。进一步调整BMI、体脂百分比、腰围或心肺适能对该关联影响不大。在进一步调整肌肉力量后，BMI、体脂百分比或腰围与癌症死亡率的关联不再显著（所有P≥0.1）。
较高水平的肌肉力量与男性较低的癌症死亡风险相关，独立于临床上既定的总体及中心性肥胖测量指标以及其他潜在混杂因素。
