Ruiz Jonatan R, Sui Xuemei, Lobelo Felipe, Morrow James R, Jackson Allen W, Sjöström Michael, Blair Steven N
Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden.
BMJ. 2008 Jul 1;337(7661):a439. doi: 10.1136/bmj.a439.
To examine prospectively the association between muscular strength and mortality from all causes, cardiovascular disease, and cancer in men.
Prospective cohort study.
Aerobics centre longitudinal study.
8762 men aged 20-80.
All cause mortality up to 31 December 2003; muscular strength, quantified by combining one repetition maximal measures for leg and bench presses and further categorised as age specific thirds of the combined strength variable; and cardiorespiratory fitness assessed by a maximal exercise test on a treadmill.
During an average follow-up of 18.9 years, 503 deaths occurred (145 cardiovascular disease, 199 cancer). Age adjusted death rates per 10,000 person years across incremental thirds of muscular strength were 38.9, 25.9, and 26.6 for all causes; 12.1, 7.6, and 6.6 for cardiovascular disease; and 6.1, 4.9, and 4.2 for cancer (all P<0.01 for linear trend). After adjusting for age, physical activity, smoking, alcohol intake, body mass index, baseline medical conditions, and family history of cardiovascular disease, hazard ratios across incremental thirds of muscular strength for all cause mortality were 1.0 (referent), 0.72 (95% confidence interval 0.58 to 0.90), and 0.77 (0.62 to 0.96); for death from cardiovascular disease were 1.0 (referent), 0.74 (0.50 to 1.10), and 0.71 (0.47 to 1.07); and for death from cancer were 1.0 (referent), 0.72 (0.51 to 1.00), and 0.68 (0.48 to 0.97). The pattern of the association between muscular strength and death from all causes and cancer persisted after further adjustment for cardiorespiratory fitness; however, the association between muscular strength and death from cardiovascular disease was attenuated after further adjustment for cardiorespiratory fitness.
Muscular strength is inversely and independently associated with death from all causes and cancer in men, even after adjusting for cardiorespiratory fitness and other potential confounders.
前瞻性研究男性肌肉力量与全因死亡率、心血管疾病死亡率和癌症死亡率之间的关联。
前瞻性队列研究。
有氧运动中心纵向研究。
8762名年龄在20 - 80岁之间的男性。
截至2003年12月31日的全因死亡率；肌肉力量，通过结合腿部和卧推的一次重复最大值测量进行量化，并进一步按综合力量变量的年龄特异性三分位数进行分类；以及通过跑步机上的最大运动测试评估的心肺适能。
在平均18.9年的随访期间，发生了503例死亡（145例心血管疾病，199例癌症）。每10000人年中，随着肌肉力量三分位数的增加，全因死亡率经年龄调整后分别为38.9、25.9和26.6；心血管疾病死亡率分别为12.1、7.6和6.6；癌症死亡率分别为6.1、4.9和4.2（所有线性趋势的P<0.01）。在调整了年龄、身体活动、吸烟、饮酒、体重指数、基线医疗状况和心血管疾病家族史后，随着肌肉力量三分位数的增加，全因死亡率的风险比分别为1.0（参照）、0.72（95%置信区间0.58至0.90）和0.77（0.62至0.96）；心血管疾病死亡的风险比分别为1.0（参照）、0.74（0.50至1.10）和0.71（0.47至1.07）；癌症死亡的风险比分别为1.0（参照）、0.72（0.51至1.00）和0.68（0.48至0.97）。在进一步调整心肺适能后，肌肉力量与全因死亡和癌症死亡之间的关联模式仍然存在；然而，在进一步调整心肺适能后，肌肉力量与心血管疾病死亡之间的关联减弱。
即使在调整了心肺适能和其他潜在混杂因素后，肌肉力量与男性的全因死亡和癌症死亡呈负相关且独立相关。
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