Burt Davina, Bruno Graziella, Chaturvedi Nish, Schalkwijk Casper, Stehouwer Coen D, Witte Daniel R, Fuller John H, Pinach Silvia, Perin Paolo Cavallo, Gruden Gabriella
Department of Internal Medicine, University of Turin, Turin, Italy.
Diabetes Care. 2009 Jul;32(7):1269-71. doi: 10.2337/dc08-2271. Epub 2009 Apr 14.
To assess whether serum anti-heat shock protein 27 (HSP27) antibody levels are associated with micro- and macrovascular complications of type 1 diabetes.
Anti-HSP27 IgG antibody levels were measured in 531 type 1 diabetic subjects recruited as part of the cross-sectional analysis of the EURODIAB Prospective Complications Study. Case subjects (n = 363) were defined as individuals with one or more diabetes complications and control subjects (n = 168) as individuals with no evidence of any diabetes complication.
Anti-HSP27 levels were comparable in case and control subjects (19.6 arbitrary units/ml [11.3-32.7] vs. 20.4 arbitrary units/ml [11.7-35.3], geometric mean [interquartile range]), and there was no correlation between HSP27 and anti-HSP27 levels (r = 0.01, P = 0.81). In logistic regression analysis, anti-HSP27 was not associated with the presence of complications, even after adjustment for main risk factors.
Anti-HSP27 antibody levels are not a marker of vascular complications in type 1 diabetes.
评估血清抗热休克蛋白27（HSP27）抗体水平是否与1型糖尿病的微血管和大血管并发症相关。
在作为欧洲糖尿病前瞻性并发症研究横断面分析一部分招募的531例1型糖尿病患者中测量抗HSP27 IgG抗体水平。病例组（n = 363）定义为患有一种或多种糖尿病并发症的个体，对照组（n = 168）定义为无任何糖尿病并发症证据的个体。
病例组和对照组的抗HSP27水平相当（几何平均数[四分位间距]分别为19.6任意单位/毫升[11.3 - 32.7]与20.4任意单位/毫升[11.7 - 35.3]），且HSP27与抗HSP27水平之间无相关性（r = 0.01，P = 0.81）。在逻辑回归分析中，即使在对主要危险因素进行校正后，抗HSP27与并发症的存在也无关。
抗HSP27抗体水平不是1型糖尿病血管并发症的标志物。
