重度抑郁症患者与夜间饮食综合征患者血清素转运体结合亲和力的差异。
Differences in serotonin transporter binding affinity in patients with major depressive disorder and night eating syndrome.
作者信息
Lundgren J D, Amsterdam J, Newberg A, Allison K C, Wintering N, Stunkard A J
机构信息
Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania School of Medicine, Philapelphia, PA, USA.
出版信息
Eat Weight Disord. 2009 Mar;14(1):45-50. doi: 10.1007/BF03327794.
OBJECTIVE
We examined serotonin transporter (SERT) binding affinity using single photon emission computed tomography (SPECT) in patients with major depressive disorder (MDD) and night eating syndrome (NES). There are similarities between MDD and NES in affective symptoms, appetite disturbance, nighttime awakenings, and, particularly, response to selective serotonin reuptake inhibitors (SSRIs).
METHODS
Six non-depressed patients with NES and seven patients with MDD underwent SPECT brain imaging with 123I-ADAM, a radiopharmaceutical agent selective for SERT sites. Uptake ratios of 123I-ADAM SERT binding were obtained for the midbrain, basal ganglia, and temporal lobe regions compared to the cerebellum reference region.
RESULTS
Patients with NES had significantly greater SERT uptake ratios (effect size range 0.64-0.84) in the midbrain, right temporal lobe, and left temporal lobe regions than those with MDD whom we had previously studied.
CONCLUSIONS
Pathophysiological differences in SERT uptake between patients with NES and MDD suggest these are distinct clinical syndromes.
目的
我们使用单光子发射计算机断层扫描（SPECT）检查了重度抑郁症（MDD）和夜间进食综合征（NES）患者的血清素转运体（SERT）结合亲和力。MDD和NES在情感症状、食欲紊乱、夜间觉醒方面存在相似之处，尤其是在对选择性5-羟色胺再摄取抑制剂（SSRI）的反应方面。
方法
6名非抑郁的NES患者和7名MDD患者接受了用123I-ADAM进行的SPECT脑成像，123I-ADAM是一种对SERT位点有选择性的放射性药物。与小脑参考区域相比，获得了中脑、基底神经节和颞叶区域的123I-ADAM SERT结合摄取率。
结果
与我们之前研究过的MDD患者相比，NES患者在中脑、右侧颞叶和左侧颞叶区域的SERT摄取率显著更高（效应大小范围为0.64 - 0.84）。
结论
NES患者和MDD患者在SERT摄取方面的病理生理差异表明这是两种不同的临床综合征。
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