Department of Psychology, University of Missouri-Kansas City, 5030 Cherry Street, Kansas City, MO, 64110, USA.
Curr Obes Rep. 2014 Mar;3(1):79-90. doi: 10.1007/s13679-013-0082-7.
The development and maintenance of night eating syndrome (NES) is likely influenced by physiological, psychological, and social factors. Within the physiological domain, neural mechanisms (e.g., neurotransmitters and specific brain region functioning) remain understudied in contrast to other eating disorders and obesity. The serotonin system has been hypothesized to contribute to NES based on one single photon emission computed tomography (SPECT) study and supportive pharmacologic treatment outcome findings, but additional neural models are plausible. Functional magnetic resonance imaging (fMRI) is a brain imaging tool that is increasingly being used to study obesity, eating behavior, and sleep. Converging data from these literatures using food motivation and decision making fMRI paradigms suggest that the prefrontal and limbic brain systems might also play a role in the development and/or maintenance of NES. We use these data to support a new neural model of NES for future testing and validation.
夜食症候群（NES）的发展和维持可能受到生理、心理和社会因素的影响。在生理领域，与其他饮食失调和肥胖症相比，神经机制（例如神经递质和特定脑区的功能）的研究仍不够充分。基于一项单光子发射计算机断层扫描（SPECT）研究和支持的药物治疗结果发现，血清素系统可能与 NES 有关，但也存在其他神经模型的可能性。功能磁共振成像（fMRI）是一种越来越多地用于研究肥胖、饮食行为和睡眠的脑成像工具。使用食物动机和决策 fMRI 范式从这些文献中得出的趋同数据表明，前额叶和边缘脑系统也可能在 NES 的发展和/或维持中发挥作用。我们使用这些数据来支持 NES 的新神经模型，以进行未来的测试和验证。
