Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China.
Phytother Res. 2009 Dec;23(12):1742-7. doi: 10.1002/ptr.2837.
The major purpose of this study was to determine the effect of procyanidins extracted from the lotus seedpod (LSPC) on the learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) in mice. The capacities of memory and learning were evaluated by the Morris water maze and the step-down avoidance test. LSPC (50, 100, 150 mg/kg BW, p.o.) significantly reversed scopolamine-induced learning and memory impairments in the Morris water maze test, as evaluated by shortened escape latency and swimming distance. In the step-down avoidance test, LSPC (50, 100, 150 mg/kg BW, p.o.) treatment significantly reduced the number of errors and shortened latency compared with that of scopolamine. In addition, LSPC was also found to inhibit acetyl cholinesterase (AChE) activity. These results of this study suggest that LSPC may play a useful role in the treatment of cognitive impairment caused by AD and aging.
本研究的主要目的是确定从莲子壳中提取的原花青素（LSPC）对东莨菪碱（1mg/kg，腹腔注射）诱导的小鼠学习和记忆损伤的影响。通过 Morris 水迷宫和避错实验评估记忆和学习能力。LSPC（50、100、150mg/kg BW，po）显著逆转了东莨菪碱诱导的 Morris 水迷宫试验中的学习和记忆损伤，表现为逃避潜伏期和游泳距离缩短。在避错实验中，LSPC（50、100、150mg/kg BW，po）治疗组与东莨菪碱组相比，错误次数减少，潜伏期缩短。此外，还发现 LSPC 能抑制乙酰胆碱酯酶（AChE）活性。本研究结果表明，LSPC 可能在治疗 AD 和衰老引起的认知障碍方面发挥有益作用。
