Klaus H, Lommatzsch P K, Fuchs U
Augenklinik Universität Leipzig, Federal Republic of Germany.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):480-6. doi: 10.1007/BF00166314.
Choroidal malignant melanomas were examined after unsuccessful brachytherapy with 106Ru/106Rh ophthalmic plaques. The histologic findings were compared with those obtained in non-irradiated melanomas similar in size and location. Both groups revealed no significant clinical difference apart from the lower average age of the irradiated patients. Some of the histologic features (scar formation, changes in the distribution of cell types, rate of mitosis) represented reactions to irradiation. No single histologic feature was strongly correlated to the irradiated group. The phenomenon of radioinsensitivity observed in some malignant melanomas cannot be fully elucidated using conventional histologic methods.
对采用¹⁰⁶Ru/¹⁰⁶Rh眼用敷贴器进行近距离放射治疗失败后的脉络膜恶性黑色素瘤进行了检查。将组织学结果与在大小和位置相似的未照射黑色素瘤中获得的结果进行比较。除了接受照射患者的平均年龄较低外，两组在临床上没有显著差异。一些组织学特征（瘢痕形成、细胞类型分布变化、有丝分裂率）代表了对辐射的反应。没有单一的组织学特征与照射组有强烈关联。使用传统组织学方法无法完全阐明在一些恶性黑色素瘤中观察到的放射不敏感现象。
