伊朗薄荷状荆芥精油的抗菌活性及成分

Antibacterial activity and composition of the essential oil of Nepeta menthoides from Iran.

作者信息

Sonboli Ali, Gholipour Abbas, Yousefzadi Morteza, Mojarrad Mehran

机构信息

Department of Biology, Medicinal Plants and Drugs Res. Inst., Shahid Beheshti University, G.C., Evin, 1983963113, Tehran, Iran.

出版信息

Nat Prod Commun. 2009 Feb;4(2):283-6.

PMID:19370940

Abstract

The antibacterial activity and chemical composition of the essential oil obtained from the aerial flowering parts of Nepeta menthoides were analyzed by GC and GC-MS. Twenty-nine compounds representing 97.6% of the total oil were identified. Oxygenated monoterpenes (71.9%) were the principal fraction of the oil with 1,8-cineole (33.8%) and 4aa-7alpha-7aalpha-nepetalactone (23.2%) as the main constituents. The antibacterial activity of the oil and its two main constituents were tested against seven bacteria. High activity of the oil and its two main constituents was demonstrated against all the tested bacteria with MIC values in the range of 1.8 - 7.2, 0.9 - 7.2 and 1.8 - 15 mg/mL, respectively.

摘要

采用气相色谱（GC）和气相色谱-质谱联用（GC-MS）技术分析了留兰香荆芥地上开花部分精油的抗菌活性和化学成分。共鉴定出29种化合物，占精油总量的97.6%。氧化单萜类化合物（71.9%）是精油的主要成分，其中1,8-桉叶素（33.8%）和4aa-7α-7aα-荆芥内酯（23.2%）为主要成分。测试了该精油及其两种主要成分对7种细菌的抗菌活性。结果表明，该精油及其两种主要成分对所有测试细菌均具有高活性，其最低抑菌浓度（MIC）值分别在1.8 - 7.2、0.9 - 7.2和1.8 - 15 mg/mL范围内。