Sonboli A, Saadat M H, Arman M, Kanani M R
a Department of Biology, Medicinal Plants and Drugs Research Institute , Shahid Beheshti University , Tehran , Iran.
b Pharmaceutical Sciences Branch , Islamic Azad University (IAU) , Tehran , Iran.
Nat Prod Res. 2017 Dec;31(23):2806-2809. doi: 10.1080/14786419.2017.1295237. Epub 2017 Mar 1.
The composition and antibacterial activity of the essential oil of the aerial flowering parts of Nepeta hormozganica Jamzad have been studied. Analysis of the oil was conducted by GC-FID and GC-MS. Thirty-two components were characterized accounting for 99.4% of the total oil. Oxygenated monoterpenes (87.5%) were found to be the predominant group of compounds, of which 18-cineole (65.0%) and 4aα-7α-7aβ-nepetalactone (13.0%) were the main constituents. The antibacterial activity of the essential oil and its main constituents showed that all of the tested microorganisms were highly inhibited by the essential oil with inhibition zones ranged from 12 to 24 mm. The most sensitive bacteria were Staphylococcus aureus and Staphylococcus epidermidis with the lowest MIC values of 0.3 and 0.6 mg/mL, respectively. Considering sensitivity screening it is conceivable that the activity of the oil from N. hormozganica could be attributed mainly to the synergistic property of 18-cineole and nepetalactone.
已对霍木兹甘荆芥（Nepeta hormozganica Jamzad）地上开花部分精油的成分和抗菌活性进行了研究。通过气相色谱-火焰离子化检测器（GC-FID）和气相色谱-质谱联用仪（GC-MS）对该精油进行了分析。鉴定出32种成分，占精油总量 的99.4%。含氧单萜（87.5%）被发现是主要的化合物类别，其中1,8-桉叶素（65.0%）和4aα-7α-7aβ-荆芥内酯（13.0%）是主要成分。精油及其主要成分的抗菌活性表明，所有受试微生物均受到精油的高度抑制，抑菌圈范围为12至24毫米。最敏感的细菌是金黄色葡萄球菌和表皮葡萄球菌，最低最低抑菌浓度（MIC）值分别为0.3和0.6毫克/毫升。考虑到敏感性筛选，可以推测霍木兹甘荆芥精油的活性可能主要归因于1,8-桉叶素和荆芥内酯的协同特性。
