Zhang Hailong, Matsuda Hisashi, Yamashita Chihiro, Nakamura Seikou, Yoshikawa Masayuki
Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan.
Eur J Pharmacol. 2009 Mar 15;606(1-3):255-61. doi: 10.1016/j.ejphar.2009.01.005. Epub 2009 Jan 17.
Hydrangeic acid (3-100 microM), a stilbene constituent of the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium), promoted adipogenesis of 3T3-L1 cells. Hydrangeic acid significantly increased the amount of adiponectin released into the medium, the uptake of 2-deoxyglucose into the cells, and the translocation of glucose transporter 4 (GLUT4). Hydrangeic acid also increased mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma2 (PPARgamma2), GLUT4, and fatty acid-binding protein (aP2) while it decreased the expression of tumor necrosis factor alpha (TNF-alpha) mRNA. However, it did not activate PPARgamma directly different from troglitazone in a nuclear receptor cofactor assay system. Furthermore, hydrangeic acid significantly lowered blood glucose, triglyceride, and free fatty acid levels after its administration for 2 weeks at a dose of 200 mg/kg/day (p.o.) in KK-A(y) mice.
绣球酸（3 - 100微摩尔）是绣球花变种（Hydrangeae Dulcis Folium）加工叶片中的一种芪类成分，可促进3T3 - L1细胞的脂肪生成。绣球酸显著增加了释放到培养基中的脂联素量、细胞对2 - 脱氧葡萄糖的摄取以及葡萄糖转运蛋白4（GLUT4）的转位。绣球酸还增加了脂联素、过氧化物酶体增殖物激活受体γ2（PPARγ2）、GLUT4和脂肪酸结合蛋白（aP2）的mRNA水平，同时降低了肿瘤坏死因子α（TNF - α）mRNA的表达。然而，在核受体辅因子测定系统中，它与曲格列酮不同，不能直接激活PPARγ。此外，在KK - A(y)小鼠中，以200毫克/千克/天（口服）的剂量给药2周后，绣球酸显著降低了血糖、甘油三酯和游离脂肪酸水平。
