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白细胞介素-4 和 -13 及其受体在胃癌和结肠癌中的可能作用。

Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.

机构信息

Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

出版信息

Int J Mol Sci. 2021 Jan 13;22(2):727. doi: 10.3390/ijms22020727.

DOI:10.3390/ijms22020727
PMID:33450900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7828336/
Abstract

Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα/IL-13Rα1) is expressed in solid tumors. While IL-13 can also bind to three different receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After receptor binding, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in gastric or colon cancer. This review summarizes the results about the role of IL-4/IL-13 and their receptors in gastric and colon cancer.

摘要

白细胞介素 (IL)-4 和 -13 是结构和功能相关的细胞因子，它们共享共同的受体亚基。它们调节免疫反应，而且还参与多种人类肿瘤的发病机制。已经描述了三种不同的 IL-4 受体，但只有 IL-4 受体 II 型 (IL-4Rα/IL-13Rα1) 在实体瘤中表达。虽然 IL-13 也可以结合到三种不同的受体上，但 IL-13 受体 I 型 (IL-4Rα/IL-13Rα1/IL-13Rα2) 和 II 型 (IL-4Rα/IL-13Rα1) 在实体瘤中表达。受体结合后，IL-4 和 IL-13 可以介导胃癌或结肠癌中的肿瘤细胞增殖、存活和转移。这篇综述总结了 IL-4/IL-13 及其受体在胃癌和结肠癌中的作用的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/7828336/63efeec6492d/ijms-22-00727-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/7828336/63efeec6492d/ijms-22-00727-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/7828336/63efeec6492d/ijms-22-00727-g001.jpg

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Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.

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本文引用的文献

[1]
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Curr Treat Options Oncol. 2020-7-28

[2]
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[3]
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J Cachexia Sarcopenia Muscle. 2020-6

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Protein Tyrosine Phosphatase-1B Inhibition Disrupts IL13Rα2-Promoted Invasion and Metastasis in Cancer Cells.

Cancers (Basel). 2020-2-21

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Int J Clin Exp Pathol. 2017-8-1

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World J Stem Cells. 2019-11-26

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J Clin Pathol. 2019-11-25

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Cytokine Growth Factor Rev. 2019-10-24

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