Rosen Clifford J, Klibanski Anne
Maine Medical Center Research Institute, Scarborough, ME 04074, USA.
Am J Med. 2009 May;122(5):409-14. doi: 10.1016/j.amjmed.2008.11.027.
Disorders of body composition, including obesity and osteoporosis, have reached record proportions. Coincidentally, our understanding of the mechanisms controlling body mass also has greatly improved. Shared regulation at the hypothalamus and the bone marrow highlight major bone-fat interactions. The hypothalamus modulates fat and bone via the sympathetic nervous system by regulating appetite, insulin sensitivity, energy use, and skeletal remodeling. In the bone marrow, fat and bone cells arise from the same stem cells. Insights from disorders such as anorexia nervosa provide a new rationale for examining the mechanisms that link bone to fat. This article explores these relationships in the context of a new paradigm with implications for obesity and osteoporosis.
包括肥胖和骨质疏松症在内的身体成分紊乱已达到创纪录的比例。巧合的是，我们对控制体重机制的理解也有了很大提高。下丘脑和骨髓的共同调节突出了主要的骨-脂肪相互作用。下丘脑通过调节食欲、胰岛素敏感性、能量利用和骨骼重塑，经由交感神经系统调节脂肪和骨骼。在骨髓中，脂肪细胞和骨细胞起源于相同的干细胞。神经性厌食症等疾病的研究见解为研究将骨骼与脂肪联系起来的机制提供了新的理论依据。本文在一个对肥胖和骨质疏松症有影响的新范式背景下探讨了这些关系。
