Consortium for Translational Research in Advanced Imaging and Nanomedicine, St Louis, MO 63108, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Jul-Aug;2(4):431-40. doi: 10.1002/wnan.87.
Fluorine (19F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (1H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19F-containing compounds in vivo. Additionally, the MR spectra of 19F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R1) and the absolute quantity of molecule can be determined with 19F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells.
氟（19F）是一种很有前途的定量磁共振成像（MRI）造影剂。它的磁共振（MR）灵敏度与质子（1H）相当，但没有组织背景信号，可以特异性和选择性地评估体内给予的含 19F 化合物。此外，含 19F 化合物的 MR 谱显示出很宽的化学位移范围（>200 ppm）。因此，19F MRI 可以通过测量 MR 参数（如自旋-晶格弛豫率 R1）和分子的绝对数量来确定，从而对组织生理学和病理学进行无偏评估。本文综述了定量 19F MRI 在肿瘤氧合成像、血管疾病分子表达评估和标记干细胞示踪中的应用。
