伤寒沙门菌Ty21a疫苗对幼儿的免疫原性。
Immunogenicity of Salmonella typhi Ty21a vaccine for young children.
作者信息
Murphy J R, Grez L, Schlesinger L, Ferreccio C, Baqar S, Muñoz C, Wasserman S S, Losonsky G, Olson J G, Levine M M
机构信息
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.
出版信息
Infect Immun. 1991 Nov;59(11):4291-3. doi: 10.1128/iai.59.11.4291-4293.1991.
Abstract
An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less than or equal to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular immune response to S. typhi. The vaccine used was known to be immunogenic for older children and adults. The results support the view that the immunogenicity of Ty21a is age dependent.
摘要
对18名婴幼儿（年龄小于或等于24个月）接种了减毒伤寒沙门氏菌Ty21a疫苗，以确定其安全性和免疫原性。疫苗接种（每剂10⁹CFU，共三剂）耐受性良好。然而，接种疫苗后，没有证据表明对伤寒沙门氏菌有体液或细胞免疫反应。已知所用疫苗对大龄儿童和成人具有免疫原性。这些结果支持Ty21a的免疫原性取决于年龄这一观点。
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