伤寒Ty21a疫苗在泰国幼儿中的安全性和免疫原性。
Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children.
作者信息
Cryz S J, Vanprapar N, Thisyakorn U, Olanratmanee T, Losonsky G, Levine M M, Chearskul S
机构信息
Swiss Serum and Vaccine Institute, Berne.
出版信息
Infect Immun. 1993 Mar;61(3):1149-51. doi: 10.1128/iai.61.3.1149-1151.1993.
Abstract
Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.
摘要
对634名2至6岁的泰国儿童评估了液体制剂的伤寒沙门氏菌Ty21a疫苗。接种疫苗者的血清转化率为69%，而接种安慰剂者为14%（P<0.005）。疫苗接种者的免疫反应范围从3岁儿童的60%到6岁儿童的81%。
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