γ干扰素激活的人巨噬细胞与刚地弓形虫、鹦鹉热衣原体和杜氏利什曼原虫：限制细胞内铁的抗菌作用
Gamma interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron.
作者信息
Murray H W, Granger A M, Teitelbaum R F
机构信息
Division of Infectious Diseases, Cornell University Medical College, New York, New York 10021.
出版信息
Infect Immun. 1991 Dec;59(12):4684-6. doi: 10.1128/iai.59.12.4684-4686.1991.
Abstract
Iron-saturated transferrin did not reverse the intracellular killing or inhibition of Toxoplasma gondii, Chlamydia psittaci, or Leishmania donovani by gamma interferon-activated human macrophages. Deferoxamine, an iron chelator, also did not impair replication within unstimulated macrophages. Limiting the availability of intracellular iron is an unlikely mechanism in human macrophage activity against these three diverse pathogens.
摘要
铁饱和转铁蛋白并不能逆转γ干扰素激活的人巨噬细胞对刚地弓形虫、鹦鹉热衣原体或杜氏利什曼原虫的细胞内杀伤或抑制作用。铁螯合剂去铁胺也不会损害未受刺激的巨噬细胞内的病原体复制。限制细胞内铁的可用性不太可能是人巨噬细胞针对这三种不同病原体发挥活性的机制。
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本文引用的文献
1
Role of iron in intracellular growth of Trypanosoma cruzi.铁在克氏锥虫细胞内生长中的作用。
Infect Immun. 1984 Sep;45(3):726-30. doi: 10.1128/iai.45.3.726-730.1984.
2
Killing of intracellular Leishmania donovani by human mononuclear phagocytes. Evidence for oxygen-dependent and -independent leishmanicidal activity.人单核吞噬细胞对细胞内杜氏利什曼原虫的杀伤作用。氧依赖型和非氧依赖型杀利什曼原虫活性的证据。
J Clin Invest. 1983 Jul;72(1):32-44. doi: 10.1172/jci110972.
3
Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma.用γ干扰素进行体外处理可调节小鼠腹腔巨噬细胞中转铁蛋白受体的表达。
Cell Immunol. 1984 Dec;89(2):478-88. doi: 10.1016/0008-8749(84)90348-4.
4
Gamma-interferon modulates human monocyte/macrophage transferrin receptor expression.γ干扰素调节人单核细胞/巨噬细胞转铁蛋白受体的表达。
Blood. 1988 Jun;71(6):1590-5.
5
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J Immunol. 1986 Jul 15;137(2):689-92.
6
7
8
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9
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10
Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate.人类肺泡巨噬细胞和腹膜巨噬细胞介导抗真菌作用，与L-精氨酸氧化为亚硝酸盐或硝酸盐无关。
Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1313-9. doi: 10.1164/ajrccm/142.6_Pt_1.1313.
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