百日咳毒素B寡聚体的特性
Properties of the B oligomer of pertussis toxin.
作者信息
Nencioni L, Pizza M G, Volpini G, De Magistris M T, Giovannoni F, Rappuoli R
机构信息
Sclavo Research Center, Siena, Italy.
出版信息
Infect Immun. 1991 Dec;59(12):4732-4. doi: 10.1128/iai.59.12.4732-4734.1991.
Abstract
The B oligomer of pertussis toxin was purified from culture supernatants of Bordetella pertussis strains which do not secrete the S1 subunit. The purified B oligomer is devoid of toxicity for CHO cells and other in vivo properties of the toxin, such as leukocytosis and histamine sensitization, but it retains the abilities to agglutinate erythrocytes and to induce the proliferation of T lymphocytes. The B oligomer is also able to induce protective immunity in mice but is less potent than molecules containing the S1 subunit also.
摘要
百日咳毒素的B寡聚体是从不分泌S1亚基的百日咳博德特氏菌菌株的培养上清液中纯化得到的。纯化后的B寡聚体对CHO细胞无毒，也没有毒素的其他体内特性，如白细胞增多和组胺致敏，但它保留了凝集红细胞和诱导T淋巴细胞增殖的能力。B寡聚体也能够在小鼠中诱导保护性免疫，但效力也低于含有S1亚基的分子。
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