Barneoud P, Le Moal M, Neveu P J
Laboratoire de Psychobiologie des Comportements Adaptatifs INSERM U. 259, Université de Bordeaux II, France.
Int J Neurosci. 1991 Jan-Feb;56(1-4):283-94. doi: 10.3109/00207459108985426.
Neurochemical changes induced by right or left cortical ablation which have previously been described to have immunological effects were investigated in mice. Catecholamine and indolamine levels were determined in the contralateral cortex and in subcortical structures involved in immunoregulation 14 and 60 days after unilateral cortical ablation. Unilateral cortical ablation induced profound and widespread changes in the contralateral cortex but also in subcortical regions of both sides at 14 days after surgery. Lesions of the left neocortex appeared mainly to affect the activity of serotoninergic inputs to the right neocortex, whereas ablations of the right cortex influenced the activity of the catecholaminergic inputs to the left. Sixty days after surgery, modifications in monoamine levels were observed only in the ipsilateral, but not contralateral, subcortical regions, the only exception being that DA turnover in the tuberoinfundibular system remained lowered in both hemispheres after either right or left cortical ablations. Furthermore, some asymmetrical effects of cortical lesions depended on functional brain lateralization as assessed by paw preference. It may be hypothesized that some neurochemical modifications induced by unilateral cortical lesions are, at least partially, responsible for the immunological perturbations observed after cortical ablation.
在小鼠中研究了先前已被描述具有免疫作用的右或左皮质切除所诱导的神经化学变化。在单侧皮质切除术后14天和60天，测定对侧皮质以及参与免疫调节的皮质下结构中的儿茶酚胺和吲哚胺水平。单侧皮质切除在术后14天不仅在对侧皮质而且在双侧皮质下区域都引起了深刻而广泛的变化。左侧新皮质的损伤似乎主要影响右新皮质中血清素能输入的活性，而右侧皮质的切除则影响左新皮质中儿茶酚胺能输入的活性。术后60天，仅在同侧皮质下区域观察到单胺水平的改变，对侧未观察到，唯一的例外是，无论右或左皮质切除后，双侧的结节漏斗系统中的多巴胺周转率均保持降低。此外，皮质损伤的一些不对称效应取决于通过爪偏好评估的功能性脑侧化。可以推测，单侧皮质损伤所诱导的一些神经化学改变至少部分地是皮质切除后观察到的免疫紊乱的原因。
