Barnéoud P, le Moal M, Neveu P J
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U. 259, Universitè de Bordeaux, France.
Brain Res. 1990 Jun 18;520(1-2):317-21. doi: 10.1016/0006-8993(90)91721-r.
Biogenic amine distributions analyzed in the cerebral neocortex, striatum, anterior hypothalamus, and bulbospinal region, were compared between both hemispheres of left- and right-handed mice. The handedness of mice was determined using a paw preference test. The animals were tested 5 times, once every two weeks, and the biochemical analysis was performed two weeks after the last behavioral evaluation. The results indicated that (1) asymmetrical monoaminergic concentrations exist in the mouse brain. Monoamine contents were found to be higher in the right parietal cortex and anterior hypothalamus than in the left ones; (2) besides the behavioral expression of handedness, left- and right-handed subpopulations of mice differ according to asymmetrical distributions of cortical and bulbospinal NE contents as well as DA turnover of the tuberoinfundibular system.
在左利手和右利手小鼠的两个半球之间，比较了在大脑新皮质、纹状体、下丘脑前部和延髓脊髓区域分析的生物胺分布。使用爪子偏好测试确定小鼠的利手性。对动物进行了5次测试，每两周测试一次，并且在最后一次行为评估后两周进行生化分析。结果表明：（1）小鼠脑中存在不对称的单胺能浓度。发现右顶叶皮质和下丘脑前部的单胺含量高于左部；（2）除了利手性的行为表现外，左利手和右利手小鼠亚群在皮质和延髓脊髓去甲肾上腺素含量的不对称分布以及结节漏斗系统的多巴胺周转率方面存在差异。
