Shanghai Jiao Tong University, Affiliated Sixth People's Hospital Shanghai, China.
Adv Ther. 2009 Apr;26(4):425-34. doi: 10.1007/s12325-009-0020-y. Epub 2009 Apr 16.
Ultrasound contrast agents are not only effective in ultrasonic imaging but are also important tools for drug or gene delivery. Ultrasound beams can disrupt microbubbles and cell membranes, offering the opportunity to locally deliver drugs or genes. Liposome-shelled microbubbles have many advantages and are widely used in many applications, while Lipofectamine (Invitrogen, Life Technologies, Carlsbad, CA, USA), as a material of microbubble membranes, has been used to enhance the effects of gene delivery. Ultrasound contrast agents that have therapeutic effects can be used for treating peripheral vascular diseases, particularly in thrombotic and angiogenic diseases. A combination of targeted contrast agent and drug-carrying contrast agent may be safer and more effective in treating thrombosis. Vascular endothelial growth factor-loaded microbubbles are expected to treat a variety of neovascular diseases such as severe limb ischemia and other diseases. Although there are several limitations in the application of therapeutic ultrasound microbubble contrast agents, it will offer a new hope for the treatment of peripheral vascular disease.
超声造影剂不仅在超声成像中具有重要作用,也是药物或基因传递的重要工具。超声束可以破坏微泡和细胞膜,为局部递药或基因提供了机会。脂质体壳微泡具有许多优点,广泛应用于许多领域,而 Lipofectamine(Invitrogen,Life Technologies,Carlsbad,CA,USA)作为微泡膜的材料,已被用于增强基因传递的效果。具有治疗作用的超声造影剂可用于治疗外周血管疾病,特别是在血栓形成和血管生成疾病中。靶向造影剂与载药造影剂的联合应用可能在治疗血栓形成方面更安全、更有效。载有血管内皮生长因子的微泡有望治疗各种新生血管疾病,如严重肢体缺血等疾病。尽管治疗性超声微泡造影剂的应用存在一些局限性,但它将为外周血管疾病的治疗提供新的希望。