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通过微波辐射促进的迈克尔加成反应合成γ-硝基脂肪族甲酯。

Synthesis of gamma-nitro aliphatic methyl esters via Michael additions promoted by microwave irradiation.

作者信息

Escalante Jaime, Díaz-Coutiño Francisco D

机构信息

Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos. Cuernavaca, Mor., Mexico.

出版信息

Molecules. 2009 Apr 21;14(4):1595-604. doi: 10.3390/molecules14041595.

DOI:10.3390/molecules14041595
PMID:19384288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6254152/
Abstract

A simple and efficient protocol has been developed for the direct synthesis of gamma-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.

摘要

已经开发出一种简单有效的方法，用于在微波辐射下直接合成γ-硝基丁酸甲酯。与传统条件相比，该方法将反应时间从数天缩短至数分钟。此外，这些条件提高了产率并提供了更纯净的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/05736b51575e/molecules-14-01595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/9d2273c951ef/molecules-14-01595-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/1ff5dafaac54/molecules-14-01595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/d0f6fea38647/molecules-14-01595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/ce4ae9d4127d/molecules-14-01595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/5f07a385a33e/molecules-14-01595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/05736b51575e/molecules-14-01595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/9d2273c951ef/molecules-14-01595-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/1ff5dafaac54/molecules-14-01595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/d0f6fea38647/molecules-14-01595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/ce4ae9d4127d/molecules-14-01595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/5f07a385a33e/molecules-14-01595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e58/6254152/05736b51575e/molecules-14-01595-g006.jpg

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本文引用的文献

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Accelerating lead development by microwave-enhanced medicinal chemistry.通过微波强化药物化学加速先导化合物开发。
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Michael additions of amines to methyl acrylates promoted by microwave irradiation.微波辐射促进胺对丙烯酸甲酯的迈克尔加成反应。
Molecules. 2008 Feb 7;13(2):340-7. doi: 10.3390/molecules13020340.
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