美国出生的艾滋病毒感染者和移民中的破伤风抗体保护情况。
Tetanus antibody protection among HIV-infected US-born patients and immigrants.
作者信息
Alagappan K, McGowan J, DeClaro D, Ng D, Silverman R A
机构信息
Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, USA.
出版信息
Int J Emerg Med. 2008 Jun;1(2):123-6. doi: 10.1007/s12245-008-0020-8.
INTRODUCTION
Public health initiatives to immunize children and adults have effectively reduced the number of tetanus cases in the USA. However, in the Third National Health and Nutrition Examination Survey (NHANES III), immigrants from Mexico had a 67% nonprotective anti-tetanus antibody (ATA) level. Less work has been conducted among other vulnerable populations such as human immunodeficiency virus (HIV)-infected patients. The objective of this study was to measure ATA levels among the HIV immigrant population compared with US-born HIV-infected patients.
METHODS
A convenience sample of 158 HIV-infected individuals was recruited to determine the levels of ATA. A nonprotective level of ATA was defined as below 0.15 IU/ml.
RESULTS
Among the HIV-infected patients, 72% (114/158) were born in the USA. A total of 17% (27/158) lacked protective levels of ATA. A total of 6.1% (7/114) of those born in the USA lacked protection, compared to 45% (20/44) born outside the USA (p < 0.0001).
CONCLUSION
The results illustrate that the country of birth is an important predictor of ATA protection, even among HIV-infected patients.
引言
美国开展的儿童和成人免疫公共卫生举措已有效减少破伤风病例数量。然而，在第三次全国健康与营养检查调查（NHANES III）中，来自墨西哥的移民破伤风抗毒素（ATA）抗体水平无保护作用的比例达67%。在其他弱势群体（如感染人类免疫缺陷病毒（HIV）的患者）中开展的相关研究较少。本研究的目的是比较HIV感染移民人群与美国出生的HIV感染患者的ATA水平。
方法
选取158例HIV感染个体的便利样本，以确定ATA水平。ATA无保护作用水平定义为低于0.15 IU/ml。
结果
在HIV感染患者中，72%（114/158）在美国出生。共有17%（27/158）的患者ATA水平缺乏保护作用。在美国出生的患者中，6.1%（7/114）缺乏保护，而在美国以外出生的患者中这一比例为45%（20/44）（p<0.0001）。
结论
结果表明，即使在HIV感染患者中，出生国家也是ATA保护作用的重要预测因素。
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