65岁以上成年人破伤风抗体血清阳性率。
Seroprevalence of tetanus antibodies among adults older than 65 years.
作者信息
Alagappan K, Rennie W, Kwiatkowski T, Falck J, Silverstone F, Silverman R
机构信息
Department of Emergency Medicine, Long Island Jewish Medical Center, Bronx, New York, USA.
出版信息
Ann Emerg Med. 1996 Jul;28(1):18-21. doi: 10.1016/s0196-0644(96)70132-4.
STUDY OBJECTIVE
To define the extent of immunity against tetanus among patients older than 65 years of age by measuring antitetanus antibody levels.
METHODS
A convenience sample of 129 patients from an urban comprehensive care geriatric center was studied. Serum was obtained and enzyme-linked immunosorbent assay (ELISA) testing performed. Twenty health care providers, aged 25 to 40 years, were tested for comparison.
RESULTS
In 64 (50%) of 129 study patients, antitetanus antibody levels did not reach protective levels. Fifty-four (59%) of 92 women and 10 (27%) of 37 men did not have adequate titers. All 20 health care workers had protective titers.
CONCLUSION
Elderly patients are substantially less likely than young individuals to have adequate immunity against tetanus. Emergency physicians must take this into consideration when evaluating tetanus immunization status in injured elderly patients.
研究目的
通过测量抗破伤风抗体水平来确定65岁以上患者对破伤风的免疫程度。
方法
对一家城市综合护理老年中心的129名患者进行便利抽样研究。采集血清并进行酶联免疫吸附测定（ELISA）检测。选取20名年龄在25至40岁之间的医护人员进行检测以作比较。
结果
129名研究患者中有64名（50%）抗破伤风抗体水平未达到保护水平。92名女性中有54名（59%）、37名男性中有10名（27%）抗体滴度不足。所有20名医护人员的抗体滴度均具有保护性。
结论
老年患者比年轻人具有足够破伤风免疫力的可能性要低得多。急诊医生在评估受伤老年患者的破伤风免疫状况时必须考虑到这一点。
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