Santra Santimukul, Kaittanis Charalambos, Grimm Jan, Perez J Manuel
Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.
Small. 2009 Aug 17;5(16):1862-8. doi: 10.1002/smll.200900389.
A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.
一种具有生物相容性、多模态和治疗诊断功能的氧化铁纳米颗粒通过一种新型水基方法合成,具有用于靶向癌症治疗以及光学和磁共振成像的优异性能。首次采用一种简便的改进溶剂扩散法对抗癌药物和近红外染料进行共包封。所得的叶酸衍生化治疗诊断纳米颗粒可实现靶向光学/磁共振成像以及对表达叶酸的癌细胞进行靶向杀伤。