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从 Sieb. 中提取和分离两种多糖及其抗胃癌活性评价。

Extraction and Isolation of Two Polysaccharides from Sieb. and Evaluation of Their Anti-Gastric Cancer Activities.

机构信息

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Department of Drug Discovery, Guangzhou Caizhilin Pharmaceutical Co., Ltd., Guangzhou 510360, China.

出版信息

Molecules. 2024 Apr 29;29(9):2043. doi: 10.3390/molecules29092043.

DOI:10.3390/molecules29092043
PMID:38731534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085155/
Abstract

Two unreported heteropolysaccharides, denoted as YCJP-1 and YCJP-2, were isolated from the herbs of . YCJP-1 was a heteropolysaccharide composed of glucose, galactose, arabinose, mannose, rhamnose, and a minor proportion of uronic acids, with the molecular weight mainly distributed in the 74,475-228,443 Da range. YCJP-2 was mainly composed of glucose, mannose, and galactose, with the molecular weights ranging from 848 to 5810 Da. To further evaluate the anti-gastric cancer effects of , the inhibitory effects of the crude polysaccharide (YCJP) and the purified polysaccharides (YCJP-1 and YCJP-2) were determined using a CCK-8 assay and colon-forming assay on MGC-803 and AGS gastric cancer cell lines. Our results showed that YCJP, YCJP-1, and YCJP-2 possess prominent inhibitory effects on the proliferation of MGC-803 and AGS cells, and the AGS cell was more sensitive to YCJP, YCJP-1, and YCJP-2. Moreover, YCJP-2 demonstrated superior anti-gastric cancer effects compared to YCJP-1. This could potentially be attributed to YCJP-2's higher glucose content and narrower molecular weight distribution.

摘要

两种未报道的杂多糖，分别命名为 YCJP-1 和 YCJP-2，从 的药材中分离得到。YCJP-1 是一种由葡萄糖、半乳糖、阿拉伯糖、甘露糖、鼠李糖和少量糖醛酸组成的杂多糖，分子量主要分布在 74475-228443Da 范围内。YCJP-2 主要由葡萄糖、甘露糖和半乳糖组成，分子量范围为 848-5810Da。为了进一步评价 的抗胃癌作用，采用 CCK-8 法和结肠形成试验，测定了粗多糖（YCJP）和纯化多糖（YCJP-1 和 YCJP-2）对 MGC-803 和 AGS 胃癌细胞系的抑制作用。结果表明，YCJP、YCJP-1 和 YCJP-2 对 MGC-803 和 AGS 细胞的增殖均有显著的抑制作用，AGS 细胞对 YCJP、YCJP-1 和 YCJP-2 更为敏感。此外，YCJP-2 显示出比 YCJP-1 更好的抗胃癌作用。这可能归因于 YCJP-2 较高的葡萄糖含量和较窄的分子量分布。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/f1faf337f554/molecules-29-02043-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/88ebe23ca443/molecules-29-02043-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/f4d865461152/molecules-29-02043-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/5d9c8c8310fd/molecules-29-02043-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/48d94561b55f/molecules-29-02043-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/8ef46b25ff97/molecules-29-02043-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/3756c8625cee/molecules-29-02043-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/7a68a41de961/molecules-29-02043-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/f1faf337f554/molecules-29-02043-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/88ebe23ca443/molecules-29-02043-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/f4d865461152/molecules-29-02043-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/5d9c8c8310fd/molecules-29-02043-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/48d94561b55f/molecules-29-02043-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/8ef46b25ff97/molecules-29-02043-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/3756c8625cee/molecules-29-02043-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/7a68a41de961/molecules-29-02043-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a933/11085155/f1faf337f554/molecules-29-02043-g008.jpg

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