Polydorou Olga, König Armin, Hellwig Elmar, Kümmerer Klaus
Department of Operative Dentistry and Periodontology, University Medical Center Freiburg, Dental School and Hospital, 79106 Freiburg i. Br, Germany.
J Biomed Mater Res B Appl Biomater. 2009 Oct;91(1):1-4. doi: 10.1002/jbm.b.31383.
In recent years, the elution of monomers from dental materials has been a cause for public concern. Urethane dimethacrylate, commonly abbreviated to UDMA, is one of the monomers that are most often tested with regard to elution from and cytotoxicity of resin-based materials. Although each chemical name represents the chemical type, chemical structure, and molecular weight of a molecule, it does not seem to be the same with UDMA. In the present paper, the different forms of UDMA are presented. These include those used by dental manufacturers to produce composite materials and the different types of urethane dimethacrylate used in studies concerning the elution of monomers from composite materials. High-performance liquid chromatography (HPLC) is usually used to detect the eluted monomers, but it does not appear to be adequate in determining the different forms of UDMA. The combination of HPLC with mass spectrometry is shown to be able to specifically identify the compounds eluted in addition to those compounds used as standards in the various studies. The fact that the same name is given to different molecules causes confusion about the results of studies testing the elusion of monomers from composite materials and their possible toxicity.
近年来，牙科材料中单体的溶出引起了公众关注。聚氨酯二甲基丙烯酸酯，通常缩写为UDMA，是树脂基材料溶出和细胞毒性方面最常检测的单体之一。尽管每个化学名称代表一种分子的化学类型、化学结构和分子量，但对于UDMA似乎并非如此。在本文中，介绍了UDMA的不同形式。这些包括牙科制造商用于生产复合材料的UDMA，以及在关于复合材料中单体溶出的研究中使用的不同类型的聚氨酯二甲基丙烯酸酯。高效液相色谱法（HPLC）通常用于检测溶出的单体，但在确定UDMA的不同形式方面似乎并不充分。结果表明，HPLC与质谱联用能够特异性地识别除各项研究中用作标准品的化合物之外的其他溶出化合物。不同分子使用相同名称这一事实，导致了关于复合材料中单体溶出及其可能毒性的研究结果出现混淆。
